Flashcards in Pharmacology Test Three (medications only) Deck (162)
Chronic progressive disorder that affects the extrapyramidal motor tract
Destruction of part of brain that results in lack of neurotransmitter dopamine
Characteristic of parkinsons
Arms and legs very stiff, rigid
Characteristic of Parkinson's
Type of tremor where pt moves fingers as though they have a pill between thumb and finger
Characteristic of Parkinson's
Levodopa/Carbidopa (Sinemet) is classified as
Anti-Parkinsonian fixed combination
Levodopa/Carbidopa (Sinemet) works how?
Converts to dopamine within basal ganglia of brain increases dopamine concentration. Carbidopa works in periphery to reduce dopamine breakdown.
Levodopa/Carbidopa (Sinemet) side effects/adverse reactions:
Side: uncontrolled movements of face and tongue, arms, upper body (twisting twitching) nausea, vomiting, long-term therapy have dystonic movements, stiff uncontrolled movements)
Adverse: pathologic gambling
Teaching for levodopa/Carbidopa (Sinemet)
Take regularly and on time, may cause drowsiness at first, may take a few weeks to improve symptoms, can be taken with food to decrease nausea however eating food slows absorption
Pramipexole (Mirapex) is classified as
Pramipexole (Mirapex) works how?
Stimulates dopamine receptors in brain to relieve signs of Parkinson's
Side effects/adverse reactions for pramipexole (Mirapex)
Side: loss of strength, dizziness, orthostatic hypotension
Adverse: vascular disease can affect heart, cause irregular heart rhythm (atrial fibrillation)
Information/teaching for pramipexole (Mirapex)
Stand patient slowly and observe for changes in behavior such as compulsive sexual urges, gambling, shopping, etc.
Selegiline (Eldepryl) is classified as
Selegiline (Eldepryl) works how?
Inhibits enzyme that breaks down dopamine
Side/adverse effects for selegiline (Eldepryl)
Side: nausea, dizziness, syncope (fainting)
Adverse: CNS depression, orthostatic hypotension
Selegiline (Eldepryl) is sometimes given with
Donepezil (Aricept) is classified as
Donepezil (Aricept) works how?
Slows progression of Alzheimer's by about six months, also used for ADHD
Antidote for Donepezil (Aricept) is
Teaching for Donepezil (Aricept) is
Monitor behavior, best taken at bedtime, patient must understand medication is not a cure
Memantine (Namenda) is classified as
Memantine (Namenda) works how?
Affects neurotransmitters in brain
Side/adverse effects for memantine (Namenda)
Side: dizziness, headache, cough
Adverse: no known
Teaching for memantine (Namenda)
Make sure pt has adequate fluid intake
Baclofen (lioresal) is classified as
Baclofen (Lioresal) works how
Inhibits transmission of reflexes at spinal cord level
Side/adverse effects for Baclofen (Lioresal)
Side: drowsiness, loss of strength
adverse: related to withdrawal, overdose
Black box warning: abrupt withdrawal can cause severe muscle stiffness, pain
Teaching for Baclofen (Lioresal)
No alcohol or other CNS depressants, when started can cause drowsiness, no driving initially
Dantrolene (dantrium) is classified as