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PHA 037 - PHARMACOLOGY > PHASE 1 REACTIONS > Flashcards

PHASE 1 REACTIONS Flashcards

1
Q

What are the P450-dependent oxidations?

A
  • Aromatic hydroxylations
  • Aliphatic hydroxylations
  • Epoxidation
  • Oxidative dealkylation
  • N-oxidation
  • S-oxidation
  • Deamination
  • Desulfuration
  • Dechlorination
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2
Q

Amobarbital, pentobarbital, secobarbital, chlorpropamide, glutethimide, ibuprofen, meprobamate, phenylbutazone, digitoxin

A

Aliphatic hydroxylation

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3
Q

Acetanilide, amphetamine, propanolol, phenobarbital, phenytoin, phenylbutazone, warfarin, naphthalene, benzpyrene

A

Aromatic hydroxylation

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4
Q

Aldrin

A

Epoxidation

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5
Q

Morphine, ethylmorphine, caffeine, benzphetamine, aminopyrine, theophylline

A

N- dealkylation

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6
Q

Codeine, p-nitroanisole

A

O - dealkylation

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7
Q

6-methylthiopurine, methitural

A

S- dealkylation

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8
Q

Aniline, chlorphentermine

A

Primary amines

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9
Q

2-Acetylaminoflourene, acetaminophen

A

Secondary amines

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10
Q

Nicotine, methaqualone

A

Tertiary amines

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11
Q

Thioridazine, cimetidine, chlorpormazine

A

S- oxidation

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12
Q

Amphetamine, diazepam

A

Deamination

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13
Q

Thiopental, parathion

A

Desulfuration

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14
Q

Carbon tetrachloride

A

Dechlorination

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15
Q

What are the P450-independent oxidation?

A
  • flavin monooxygenase
  • hydrolyses
  • reductions
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16
Q

Chlorpromazine, Amitriptyline, methimazole, benzphetamine, nortriptyline, desipramine, propylthiouracil

A

Flavin monooxygenase

17
Q

Aspirin, succinylcholine, procaine, clofibrate, methylphenidate

A

Esters

18
Q

Procainamide, lidocaine, indomethacin

A

Amide

19
Q

Metyrapone, methadone, naloxone

A

Carbonyl reductions

20
Q

Prontosil, tartrazine

A

Azo reductions

21
Q

Nitrobenzene, chloramphenicol, clonazepam, dantrolene

A

Nitro reductions

PHA 037 - PHARMACOLOGY (19 decks)

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