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Flashcards in Physiology 3 Deck (19):
1

How and when does the juxtaglomerular apparatus increase renin release?

The macula densa release Renin in response to:
- beta-1-adrenergic stimulation
- decreased perfusion pressure
- decreased NaCl at the DCT (macula densa)

2

How and when does the JGA decrease GFR?

Increased NaCl reabsorption at the macula densa (DCT) causes the constriction of the afferent arteriole and slight dilation of the efferent.

3

Why doesn't Ang II cause reflex bradycardia?

It inhibits baroreceptors.

4

What peptide released by the heart acts as a check on the renin-angiotensin-aldosterone system?

ANP

5

If the blood osmolality is too low, but the blood volume is also too low, will ADH be secreted?

yes, blood volume takes precedence

6

Why would renal artery stenosis cause an increaes in blood pressure?

Renin release by JG cells

7

How do NSAIDs cause ACUTE renal failure?

prevent renal PG production, preventing dilation of the afferent arteriole and lowering GFR.

8

Effects of ANP

up GFR, up Na secretion at PCT w/ no compensatory reabsorption at distal nephron

9

PTH increases Ca++ reabsorption at the ____.

DCT

10

PTH causes decreased PO4--- reabsorption at the _____.

PCT

11

Aldosterone acts at the _______ to translocate _______ channels to the luminal membrane.

collecting duct (principal cell), Na+

12

PTH increases proton secretion from the _______ cells of the collecting duct.

intercalated

13

What acid-base disturbance will hyperaldosteronism cause? Why?

metabolic alkalosis d/t increased H+ excretion at the collecting duct

14

Etiology of Type 1 (distal) renal tubular acidosis?

In ability to secrete H+ at DCT.

15

risks associated w/ RTA 1

hypokalemia and Ca++ kidney stones

16

Etiology of Type 2 (proximal) RTA?

Inability to reabsorb HCO3- at the PCT

17

risks associated w/ type 2 RTA

kypokalemia and hypophosphatemic rickets

18

Etiology of Type 4 (hyperkalemic) RTA?

Hypoaldosteronism or collecting tubule insensitivity to aldo.

19

risks associated w/ RTA type 4

hypERkalemia, inhibition of ammonium excretion in PCT -> acidic urine