pituatraty Flashcards
(17 cards)
anterior pituitary gland secretes
GH prolactin FSH LH TSH ACTH
DEF OF hypopitaurysm
Hypopituitarism is the partial or complete deficiency in hormones produced by the pituitary (GH, FSH & LH, TSH and ACTH from the anterior pituitary and ADH from the posterior pituitary).
causes of panhypopitaurims
ommonly caused by surgery or radiotherapy.
GH deficiency signs
Growth hormone deficiency: central obesity, dry skin, reduced muscle strength, reduced exercise tolerance, depression , low bone density , hyperlipidemia increased risk of artheroscleoris
in adults the symptoms are more subtle whereas children is more obvious
FSH & LH deficiency
In females: oligomenorrhoea or amenorrhoea, infertility, sexual dysfunction, breast atrophy
In males: infertility, sexual dysfunction, hypogonadism, reduction in muscle mass
primary and secondary
primary -infection, radiation, tumour, compression, ishcemia , iatrogenic
secondary - a problem with the hypothalamus (releasing hormones ) or pituitary stalk injury - so a problem with the hypothalamopituatry axis
types of cells in the pit arty gland
somatotrope- GH - largest group of cells corticostrophs - ACTH lactotrophs- prolactin thyrotrophs - TSH gonadotrops- FSH + LH
effect of prolactin on fertily
males: inhibits spermatogenesis
females- inhibits ovulation
posterior
ADH- made by hypothalamus
OCYTCOIN
whats the order of loss in hypopitairsm
GH, gonadotroopins then. TSH , ACTH prolactin
cortisol deficiency
weight loss
low glucose
low sodium
delayed puberty
pitaury apoplexy
means either hemmrohage or infarction (Sheehan)
why is a Sheehan a thing even without haemorrhage and eclampsia
Proliferative hyperplasia of lactotrophs leading to glandular growth
- Increased sensitivity to hypoxemia due to higher metabolic needs
- Hyperestrogen state – increased risk of vasoconstriction
effect of compression of hypothalamus
somnolence and coma
dx of hypotiturims
differentiated from anorexia,
malnutrition, chronic liver disease
which endocrine deficiencies are life threatening
hypothyroidism and hypocotisol
synthecin test
giving synthetic ACTH and cortisol levels should rise
