Plasticity: Inhibitory Synapses Flashcards Preview

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Flashcards in Plasticity: Inhibitory Synapses Deck (16)
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1
Q

Inhibitory synapses release____ and ____

A

GABA and Glycine

2
Q

GABA can inhibit…

A

GABA can inhibit AP firing in neurons

3
Q

GABA is found in….

A

GABA is found in interneurons

4
Q

Predominant precursor for GABA is ____ which is metabolised into _____ by _____

A

Predominant precursor for GABA is Glucose which is metabolised into Glutamate by GAD (glutamic acid decarboxylase)

5
Q

GAD requires pyridoxal phosphate which is derived from _____. Lack of this leads to reduced GABA syynthesis

A

Vitamin B6

6
Q

___ and ___ can also act as GABA precursors

A

Pyruvate and Glutamine

7
Q

With reduced/loss of GABA you have loss of ______, which can cause___

A

With reduced/loss of GABA you have loss of Synaptic inhibition, which can cuase seizures

8
Q

Most GABA is converted into_____

A

Succinate, which is metabolized in the triboxylic acid cycle

9
Q

There are 3 GABA postsynaptic receptors:

A

GABAa, GABAb, GABAc
Inotropic: a & c
Metabotropic: b

10
Q

The Ion conductant in GABA receptor is:

A

Cl-

11
Q

Drugs that act as agonists of postsynaptic GABA receptors (Bensodiazepines) can treat?

A

Epilepsy, and are effective sedatives and anesthetics

12
Q

What can alter the activity of GABA receptors?

A

Alcohol

13
Q

About half the inhibitory synapses use GABA or Glycine

A

Glycine

14
Q

Glycine can be synthesised by the precursor ____

A

Serine

15
Q

If Glycine is not removed due to mutaitons in transporters, this can result in ?

A

Hyperglycinemia: seizures, mental retardation, lethargy

16
Q

What type of receptor is Glycine?

A

Inotropic??