PME3 Final Flashcards
What are the four classes of cardiovascular drugs?
I - sodium blockers
II - beta blockers
III - potassium blockers
IV - calcium blockers
What are the cardiovascular drugs toxicity signs and symptoms?
agitated
ALOC
seizures
bradycardia
hypotension
heart blocks
QRS widening
VF/VT
metabolic disturbances
electrolyte disturbances
weakness
nausea/vomiting
What is the cardiovascular drugs toxicity treatment approach?
treat symptomatically
consider:
A - suctioning, early advanced airway
B - oxygen, IPPV
C - 12 lead, serial printouts, pads on, IV fluids
D - IV access, IV fluids/glucose, maintain normothermia
CCP backup for atropine, adrenaline, sodium bicrbonate, calcium gluconate, magnesium sulphate
early hospital notification
What are the common sodium blocker drugs?
TCAs - ‘ine’ suffix
flecainide (CVS)
propafenone (CVS)
propranolol (CVS)
dextropropoxyphene (opioid)
What are the types of antidepressant drugs?
SSRIs
SNRIs
TCAs
MAOIs
What are the common SSRI drugs?
fluoxetine (prozac)
sertraline
citalopram
What are the common SNRI drugs?
venlafaxine (efexol)
desvenlafaxine
duloxetine
What are the common TCA drugs?
amitryptyline
imipramine (endep)
nortryptyline
What are the common MAOI drugs?
phenelzine
tranylcypromine
moclobemide
What are the serotonin syndrome signs and symptoms?
ALOC
agitation
hallucinations
tachypnoea
hypertension
tachycardia
diaphoresis
tremors
ocular/inducible/spontaneous clonus
muscle rigidity
hyperreflexia
hyperthermia
What is the antidepressant drugs toxicity treatment approach?
treat symptomatically
consider:
A - suctioning, early advanced airway
B - oxygen, IPPV
C - 12 lead, serial printouts, pads on
D - IV access IV fluids/IV fluids, maintain normothermia
CCP backup for sodium bicrbonate
Consult for GTN if significantly hypertensive
early hospital notification
What is the lithium drugs toxicity treatment approach?
treat symptomatically
consider:
A - suctioning, early advanced airway management
B - oxygen, IPPV
C - 12 lead, serial printouts, pads on
D - IV access IV fluids/glucose, maintain normothermia/aggressively cool hyperthermic Pt
CCP backup for sodium bicrbonate
early hospital notification
What is the anticonvulsant drugs toxicity treatment approach?
treat symptomatically
consider:
A - suctioning, early advanced airway management
B - oxygen, IPPV
C - 12 lead, serial printouts, pads on
D - IV access, IV fluids/glucose fluids, maintain normothermia/aggressively cool hyperthermic Pt
CCP backup for sodium bicrbonate
early hospital notification
What is the antipsychotic drugs toxicity treatment approach?
treat symptomatically
consider:
A - suctioning, early advanced airway management
B - oxygen, IPPV
C - 12 lead, serial printouts, pads on
D - IV access, IV fluids/glucose, maintain normothermia/aggressively cool hyperthermic Pt
CCP backup for sodium bicrbonate
early hospital notification
What are the antidepressant toxicity signs and symptoms?
agitated delirium
ALOC
seizures
lethargy
nystagmus
respiratory depression
tachycardia
hypotension
PR, QRS & QT widening
flat/inverted T waves
gastric irritation
urinary retention
hyperthermia
tremors
What are the lithium toxicity signs and symptoms?
ALOC
seizures
delirium
lethargy
nystagmus
respiratory depression
tachycardia
hypotension
QRS widening
QT prolongation
right axis deviation
gastric irritation
urinary retention
muscle rigidity
hyperthermia
What are the antipsychotics toxicity signs and symptoms?
ALOC
seizures
delirium
lethargy
nystagmus
respiratory depression
tachycardia
hypotension
QRS widening
QT prolongation
right axis deviation
gastric irritation
urinary retention
muscle rigidity
hyperthermia
What are the anticonvulsants toxicity signs and symptoms?
ALOC
seizures
delirium
lethargy
nystagmus
respiratory depression
tachycardia
hypotension
QRS widening
QT prolongation
right axis deviation
gastric irritation
urinary retention
muscle rigidity
hyperthermia
What are the ethanol toxicity signs and symptoms?
ALOC
disinhibition
ataxia
aggression/ABD
respiratory depression
hypotension
hypothermia
nausea/vomiting
What are the differential diagnosis of ethanol toxicity?
Encephalopathy
Head injury
Hypo-/hyperthermia
Intracranial infarction or haemorrhage
Metabolic disturbance
Overdose or other toxin
Post-ictal state
Psychosis
Sepsis
What is Wernicke Encephalopathy (WE)?
acute neuropsychiatric syndrome that develops in alcohol-dependent individuals as a result of thiamine (B1) deficiency
What is alcoholic ketoacidosis (AKA)?
medical condition that develops in the alcoholic patient in response to starvation
What are the alcoholic ketoacidosis (AKA) signs and symptoms?
hx of prolonged heavy alcohol misuse
bout of excessive intake terminated several days earlier by nausea, severe vomiting and abdominal pain
tachypnoea
tachycardia
hypotension
diffuse epigastric tenderness on palpation
What are the ethanol withdrawal syndrome signs and symptoms?
insomnia
visual hallucinations
seizures
delirium
tachycardia
hypertension
nausea
anorexia
coarse tremor
hyperreflexia