Post-Synaptic Receptor Trafficking Flashcards
1
Q
significance of post-synaptic receptor trafficking
A
maintains neuronal morphology once neuronal polarity is established
2
Q
types of sorting domains in neurons
A
somatoaxonal compartment
somatodendritic compartment
3
Q
importance of sorting in neurons
A
ensures localization of membrane components to the appropriate cellular domain
4
Q
neuronal mechanisms for targeting dendritic and axonal proteins
A
selective delivery
selective fusion
selective retention
5
Q
selective delivery
A
most of the axonal and dendritic proteins are sorted by the Golgi into carriers that preferentially deliver cargo to axons and dendrites
6
Q
selective fusion
A
- axonal protein carriers that only can perform surface delivery in the axons
- can traffic within dendrites but can’t fuse with the dendritic membrane
7
Q
selective retention
A
- axonal proteins are delivered alongside dendritic proteins to the dendritic plasma membrane
- axonal proteins are selective endocytosed and trafficking to the axonal membrane
8
Q
endosome
A
- intracellular compartment that accepts internalized vesicles from the plasma membrane
- sort cargo for recycling back to the plasma membrane or for lysosomal degradation
9
Q
parts of endosomal network
A
early/sorting endosomes
recycling endosomes
late endosomes
lysosomes
