Posterior pituitary Flashcards Preview

Endocrine > Posterior pituitary > Flashcards

Flashcards in Posterior pituitary Deck (16)
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1
Q

AVP increases water reabsorption via

A

aquaporin 2

2
Q

loop diuretics for SIADH

A

furosemide

Bumetanide

3
Q

Psychogenic polydypsia vs DI

A

psychogenic will have lower serum sodium (over-drinking)

3
Q

osmotic vs non-osmotic diuresis urine osmol

A

non-osmotic

osmotic >300

4
Q

presentation DI

A

polyuria

serum sodium high-normal

5
Q

causes central DI

A

autoimmue immune injury to hypothalamus / pituitary

head trauma / surgery

cerebral hypoperfusion

tumors (pituitary A, cranigiopahyrngioma, meningioma)

infiltratve disorders (sarcoidosis, histiocytosis

6
Q

polyuria with osmotic diuresis ddx testing

A

osmolal gap >10maOsm/mg = exogenous solutes

gap

7
Q

SIADH volume status

A

euvolemic (typically

9
Q

vasopressin receptor antagonists for SIADH

A

conivaptan

talvaptin

9
Q

neurogenic DI =

A

deficient production/release of AVP

10
Q

DI Rx and treatment

A

desmopressin - synthetic ADH

NSAIDs - to inhibit renal plastaglandins to stop inference with AVP

Thiazide diuretic (enhanced with amiloride)

Low salt, low protein diet

11
Q

polyuria with non-osmotic diuresis ddx testing

A

water restriction test

urine osmolaity 300 = DI

normal plasma osmal = psychogenic polydipsia

12
Q

in H20 deprivation test, if serum osmol goes above normal and urine osmol doesn’t increase, indicates___-

A

diabetes insipidous

14
Q

causes nerphrogenic DI

A

xlinked recessive disroders

hypokalemia

hypercalcemia

srenal disease

drugs

15
Q

nephrogenic DI=

A

renal resistance to AVP

16
Q

Hypovolemia with

>100mOsm/L =

A

>100mOsm = SIADH

Adrenal insufficiency

hypothyroidism