Posterior pituitary Flashcards Preview

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Flashcards in Posterior pituitary Deck (16):
1

AVP increases water reabsorption via 

aquaporin 2

2

loop diuretics for SIADH

furosemide

Bumetanide

3

Psychogenic polydypsia vs DI

psychogenic will have lower serum sodium (over-drinking)

3

osmotic vs non-osmotic diuresis urine osmol

non-osmotic

 

osmotic >300

4

presentation DI

polyuria

serum sodium high-normal

5

causes central DI

autoimmue immune injury to hypothalamus / pituitary

head trauma / surgery

cerebral hypoperfusion

tumors (pituitary A, cranigiopahyrngioma, meningioma)

infiltratve disorders (sarcoidosis, histiocytosis

6

polyuria with osmotic diuresis ddx testing

osmolal gap >10maOsm/mg = exogenous solutes

gap

7

SIADH volume status

euvolemic (typically

9

vasopressin receptor antagonists for SIADH

conivaptan

talvaptin 

9

neurogenic DI =

deficient production/release of AVP

10

DI Rx and treatment

desmopressin - synthetic ADH

NSAIDs - to inhibit renal plastaglandins to stop inference with AVP

Thiazide diuretic (enhanced with amiloride) 

Low salt, low protein diet

11

polyuria with non-osmotic diuresis ddx testing

water restriction test

urine osmolaity 300 = DI

 

normal plasma osmal = psychogenic polydipsia

12

in H20 deprivation test, if serum osmol goes above normal and urine osmol doesn't increase, indicates___-

diabetes insipidous

14

causes nerphrogenic DI

xlinked recessive disroders

hypokalemia

hypercalcemia

srenal disease

drugs

15

nephrogenic DI= 

renal resistance to AVP

16

Hypovolemia with

 

>100mOsm/L = 

 

>100mOsm = SIADH

Adrenal insufficiency

hypothyroidism