Potassium-sparing diuretics

Question 1

Drugs

Answer 1

(Aldosterone antagonists)
Spiranolactone
Eplerenone

(Sodium Ion Channel inhibitors)
Triamterene
Amiloride

Question 2

MOA

Answer 2

Aldosterone ant. block aldosterone - blocking sodium and water reabsorption and K+ excretion

Na+ ion channel inhibitors blocks sodium channel in DCT - inhibiting Na+ reabsorption and K+ excretion

Both are weak diuretics

Question 3

Indications

Answer 3

HTN
Edema
Heart failure

Question 4

SE/AE

Answer 4

Hyperkalemia (especially when taking ACEI/ARB)
Men - gynecomastia, impotence, low libido
Women - menstrual irregularity, hirsutism, breast tenderness

Black box: tumors found in animals with spiranolactone

Question 5

Patient teaching

Answer 5

Do not take K+ supplements
Recognize signs and symptoms of hyperkalemia (bradycardia, weakness, fatigue)