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Flashcards in PP Exam 3 Deck (31):
1

Mycosis Fungoides is.a neoplasia of ___

Malignant T-lymphocytes

2

What is the occurrence of MF?

1000/year

3

What age is MF diagnosed?

Incidence increases with age and an average of around 50 years

4

MF is most common in what populations?

Male and African Americans

5

Sezary syndrome is a variant of what cancer?

MF, leukemic varient with a more rapid course and prognosis of 2-5 years

6

Diagnosis of MF

skin bx

7

T1 MF

Patch phase, covers less then 10% of skin

8

T2 MF

Plaque phase, covers greater than or equal to 10% of skin surface

9

T3 MF

Tumor phase, frequently undergoes necrotic ulceration

10

T4 MF

erythroderma phase and peripheral blood involvement

11

Treatment MF

topical chemo, TSI, photophoresis

12

TSI

Low energy electrons, 6 field position, 30-36 Gy

13

Epidemiology soft tissue sarcoma

10,500 cases/year, slightly more males, African American, peaks around 5th decade, 45% occur in lower extremity

14

risk factors for soft tissue sarcomas

Past radiation exposure, Li-Fraumeni, RB1, Gardner syndorme

15

Histology soft tissue sarcomas

Malignant Fibrous histocytoma is most common. Also Lipsarcoma and leimyosarcoma and rhabdomyosarcoma is most common in children

16

Clinical presentation for soft tissue sarcoma

painless mass, weakness, increased pressure, edema

17

Diagnostic work-up STS

biopsy, MRI, CT of chest to look for dirt mets, functional of contralateral kidney

18

STS prognostic factors

Histology, respectability, large tumor, high grade, how deep

19

STS Spread

invade longitudinal, most common dist mets is lung

20

Stand of care for STS?

surgery with wide excision

21

Inscidence of endocrine cancer?

59,000 - 57,000 of which are thyroid cancers

22

Inscidence of thyroid cancer?

57,000 of which are thyroid cancers

23

Etiology of thyroid cancer

pre-pubescent radiation exposure

24

signs and symptoms fo thyroid cancer

palpable nde (95% are benign) hoarseness

25

Detection and diagnostic thyroid cancer

ultrasound to determine if nodule is solid or cystic (FNA), CT/MRI, radionuclide imaging (cold spots indicate cancer)

26

Most common histology if thyroid malignancies?

Papillary, moat common in previous radiation exposure cases, slow growing and non aggressive, 2-4 times more common in women, 3-5th decade of life, regional LN spread (cervical)

27

Follicular thyroid cancer

12-17%, 50-60 year olds, 2-4x more common in women, rare LN spread, distant mets to bone, lung, liver, and brain

28

Medullary Thyroid cancer

1-4%, arises from parafollicular or C cells, secrete calcitonin, spreads regional spread, cervical LN, Lung liver and bone

29

Most aggressive thyroid histology?

Anaplastic, 2-3%, 4x more common in women, median survival is 3 months

30

Treatment for thyroid cancer

surgery, adjacent RT, definitive RT if not a surgical candidate (60-70 Gy with portal field)

31

Prognosis thyroid cancer

80-90% NOT anaplastic