Ppt 6 Generation of Humoral Effector Mechanisms Flashcards Preview

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Flashcards in Ppt 6 Generation of Humoral Effector Mechanisms Deck (61):
1

3 functions of antibodies

1) opsonize
2) neutralize
3) activate classical complement

2

when you have a thymus independent antigen stimulating B cells reaction, you will generally not make these 3 things:

1) no memory
2) no isotype switching
3) no somatic mutation

3

thymus dependent antigen are what kind of molecules?

protein

4

thymus independent antigen are what kind of molecules?

polyvalent (lipid/carb/protein)

5

is there isotype switching in thymus dependent antigen?

yes

6

is there memory in thymus dependent antigen reaction?

yes

7

when B cells interact with T helper cells, what 3 things are needed for the interaction to take place?

MHC 2 and co-stimulation, CD40-CD40L

8

THelper 2 cells will cause B cells to have memory?

yes

9

once the costimulation (B7), MHC 2 and CD40-CD40L interaction occurs between T Helper cell and B cell, what happens?

B cell expresses receptor for cytokines

10

When complement activates, what complement product attaches to microbes? what receptor on B cells recognizes this?

C3d recognized by B cell CR 2 receptor

11

in X-linked Hyper IgM, what antibodies are deficient?

IgA, IgE and IgG

12

in X-linked Hyper IgM, what receptor is deficient?

CD40L

13

T helper cells generally stimulate B cells to have 3 things:

1) affinity maturation
2) isotype switching
3) memory

14

what is a Hapten?

antigenic molecule that can't induce immune response by itself

15

what does a hapten need to be attached to?

a large protein

16

what happens when you inject Ig into another animal?

it causes an antibody response

17

what is isotype?

means that you have different types of constant regions in different heavy chains that can be switched

18

what is allotype?

multiple alleles (variations in polypeptides) that code for the same isotype

19

what is idiotype?

a specific shape in the variable region that determines that antigen recognition

20

what antibody heavy chains have 4 domains and 1 hinge region?

IgG, IgA, IgD

21

what antibodies have 5 domains and no hinge?

IgM, IgE

22

what chain holds the different IgA dimers (trimers)?

J chain

23

what antibodies can form multimers?

IgM and IgA

24

this antibody is used for ADCC?

IgG

25

this antibody is produced after IgM

IgG

26

this antibody is actively transported through the placenta?

IgG

27

this antibody has no known function and is found on surface of B cells?

IgD

28

this antibody is bound to mast cells and basophils?

IgE

29

this antibody mediates the Type 1 Hypersensitivity?

IgE

30

this antibody protects against parasites?

IgE

31

This antibody is mainly found in secretions like tears, saliva, intestinal and respiratory tract?

IgA

32

this antibody is found in submucosa?

IgA

33

this antibody prevents binding of bacteria and viruses to the mucosa?

IgA

34

this antibody is found in breast milk?

IgA

35

this is the antibody first produced in primary response?

IgM

36

this antibody has a plasma valence of 10:

IgM

37

this antibody has a low affinity:

IgM

38

this antibody has the highest avidity of all

IgM

39

what does IgA use to gain passage into the mucosa?

the secretory component

40

what is trancytosis?

transport across the cell from the basement M to luminal surface

41

what Fc receptor is used to bind IgE to mast cells?

FceRI

42

how will antibodies protect adjacent cells from infection?

they bind to active sites of microbes before they bind to other cells

43

what F c receptor is used for IgG and is involved in ADCC by NK cells?

FcyRIIIA

44

what antibodies does FcyRI bind?

binds IgG 1 and IgG 3

45

what is FcyRI used for?

phagocytosis

46

this Fc receptor is used for feedback inhibition of B cells

FcyRIIB

47

what IgG subtypes are used in ADCC?

IgG 1 and IgG3

48

ADCC can also be used by what other cell recognizing IgE?

eosinophils

49

when an antibody has monomer valency, how will its avidity be?

low

50

when an antibody has bivalent valency, how will its avidity be?

high

51

when a antibody has polyvalent valency, how will its avidity be?

ver high

52

what is the valency of an antibody?

how many places it has to bind antigen

53

what is the affinity of an antibody?

how strong it will bind to antigen with only 1 of its receptors

54

what is the avidity of an antibody?

how strong it will bind to antigen using all of its receptors

55

how many alleles does a B cell express for an antibody heavy chain and light chain?

1 allele only

56

how does an antibody achieve diversity (3 ways)?

1) by having different combinations of heavy chains with light chains
2) by somatic hypermutation
3) combinatorial and junctional diversity

57

what starts the process of somatic hypermutation?

AID

58

what does AID do in a B cells?

class switching and somatic hypermutation

59

do you have a high Kd or low Kd when antibodies have high affinity for antigen?

low Kd

60

you need interaction of this receptor on B cells and t helper cells to have class switching from IgM

CD40-CD40L

61

this enzyme makes alterations in nucleotides the switch regions for them to be added downstream, in B cells

AID