Flashcards in PRACTICAL: Neuropathology and infectious diseases of the CNS Deck (17):
Name diseaes --> cerebellar hypoplasia
- Border disease virus
- Coche Valley Virus (N. America)
What can cause cerebellar hypoplasia in kittens?
Feline parvovirus (i.e. panleukopaenia - if kitten infected in utero
How are feline and canine parvovirus related?
canine parvo emerged from feline parvo in 1986. Canine form doesn't cause cerebellar hypoplasia (no tropism for brain) but has increased GIT tropism
Prognosis - cats with cerebellar ataxia d/t feline parvovirus
Can adapt/ compensate for the ataxia
What are spheroids?
the profiles of swollen axons - the standard response of axons to any kind of injury (e.g. crush, cut, hypoxia).
How can EHV-1 cause spheroids?
EHV-1 --> vasculitis (signs most noticeable within small arterioles and arteries of SC) --> multifocal tissue hypoxia and ischaemia --> spheroids
Method - fastest dx of EHV-1
Take bloods - send to AHT - do PCR within 3 hours
What is HBLB stance on EHV-1?
although no compulsory UK notification/reporting sceheme, they run a voluntary code of practice which encourages vets and yard owners to inform other owners on premises (as abortogenic)
What pathogen causes FIP?
MUTATED feline coronavirus (FCoV)
CS - FIP
usually subclinical or mild enteritis
Outline FIP that targets the brain?
targets ventricle lining --> inflammatory swelling --> acqueduct narrowing --> CSF builds up --> lateral ventricles --> acquired hydrocephalus d/t FIP
Describe wet form of FIP
mediated by AB (there is a TH2 dominated response). Virus-Ab complexes are trapped in small BVs --> vasculitis --> effusive/ wet FIP
Describe dry form of FIP
--> CMI with macrophages to clear infxn. Virus may mutate but destroyed before CS unless weak CMI --> granuloma formation (dry FIP)
CS -piglet - Streptococcus suis
- paddling (limbs)
- seizures immediately before death
Outline Streptococcus sui
- similar to Glasser's diseases as --> polyserositis (peritonitis, poly-arthritis, pleuritis etc)
- not an uncommon cause of cute and frequently fatal meningitis in suckling and weanling pig.
What are negri bodies?
the intracellular eosinophilic inclusion bodies in a cell that is an absolute indicator of lyssavirus (e.g. rabies)