PRACTICAL: Neuropathology and infectious diseases of the CNS Flashcards Preview

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Flashcards in PRACTICAL: Neuropathology and infectious diseases of the CNS Deck (17):
1

Name diseaes --> cerebellar hypoplasia

- BVDV
- Border disease virus
- SBV
- BTV
- Coche Valley Virus (N. America)

2

What can cause cerebellar hypoplasia in kittens?

Feline parvovirus (i.e. panleukopaenia - if kitten infected in utero

3

How are feline and canine parvovirus related?

canine parvo emerged from feline parvo in 1986. Canine form doesn't cause cerebellar hypoplasia (no tropism for brain) but has increased GIT tropism

4

Prognosis - cats with cerebellar ataxia d/t feline parvovirus

Can adapt/ compensate for the ataxia

5

What are spheroids?

the profiles of swollen axons - the standard response of axons to any kind of injury (e.g. crush, cut, hypoxia).

6

How can EHV-1 cause spheroids?

EHV-1 --> vasculitis (signs most noticeable within small arterioles and arteries of SC) --> multifocal tissue hypoxia and ischaemia --> spheroids

7

Method - fastest dx of EHV-1

Take bloods - send to AHT - do PCR within 3 hours

8

What is HBLB stance on EHV-1?

although no compulsory UK notification/reporting sceheme, they run a voluntary code of practice which encourages vets and yard owners to inform other owners on premises (as abortogenic)

9

What pathogen causes FIP?

MUTATED feline coronavirus (FCoV)

10

CS - FIP

usually subclinical or mild enteritis

11

Outline FIP that targets the brain?

targets ventricle lining --> inflammatory swelling --> acqueduct narrowing --> CSF builds up --> lateral ventricles --> acquired hydrocephalus d/t FIP

12

Describe wet form of FIP

mediated by AB (there is a TH2 dominated response). Virus-Ab complexes are trapped in small BVs --> vasculitis --> effusive/ wet FIP

13

Describe dry form of FIP

--> CMI with macrophages to clear infxn. Virus may mutate but destroyed before CS unless weak CMI --> granuloma formation (dry FIP)

14

CS -piglet - Streptococcus suis

- nystagmmus
- paddling (limbs)
- seizures immediately before death

15

Outline Streptococcus sui

= ZOONOTIC
- similar to Glasser's diseases as --> polyserositis (peritonitis, poly-arthritis, pleuritis etc)
- not an uncommon cause of cute and frequently fatal meningitis in suckling and weanling pig.

16

What are negri bodies?

the intracellular eosinophilic inclusion bodies in a cell that is an absolute indicator of lyssavirus (e.g. rabies)

17

Commonest methods to dx rabies

* IFT and IHC of brain tissue are the commonest)
- viral isolation
- PCR