Practice 2

Question 1

Acyclovir is rapidly converted to valacyclovir. T/F

Answer 1

False

Question 2

Which of the following is a precaution for acyclovir?

1. Caution in patients with pre-existing CNS impairment
2. Caution in patients with pre-existing cardiac arrhythmias
3. Caution in patients with pre-exisiting hearing loss
4. Caution in patients with pre-existing renal impairments

Answer 2

Caution in patients with pre-exiting RENAL impairments

Question 3

In regards to mechanism of action, mupirocin inhibits fungal protein synthesis. T/F

Answer 3

False

Question 4

Which of the following is contraindicated in patients with renal CrCL<60 mL/min?
Macrobid
Diflucan
Nystop
Valtrex

Answer 4

Macrobid

Question 5

Which of the following is a safety monitoring parameter for Lotrisone therapy?

1. Cushing’s syndrome
2. EKG - QTc prolongation
3. Serum Creatinine
4. Renal Failure

Answer 5

Cushing’s Syndrome

Question 6

As a precaution to prevent liver failure, adequate hydration is important throughout acyclovir therapy. T/F

Answer 6

False

Renal Failure

Question 7

Floconazole is a CYP 3A4 inducer. T/F

Answer 7

False
It is a CYP
2C9 Inhibitor
2C19 Inhibitor
3A4 Inhibitor

Question 8

Which of the following are efficacy and safety monitoring parameters of floconazole therapy? SATA.

1. LFTs
2. C. diff infection
3. EKG - QTc prolongation
4. Resolution of infection

Answer 8

LFTs
EKG - QTc prolongation
Resolution of infection

Question 9

Which of the following are efficacy and safety monitoring parameters of acyclovir therapy? SATA

1. EKG
2. LFTs
3. Resolution of infection
4. Serum Creatinine

Answer 9

LFTs
Resolution of infection
Serum Creatinine

Question 10

Which of the following increases the rate of systemic absorption of Lotrisone, therefore leading to increased risk of steroid related side effects? SATA.

1. Renal failure
2. Liver failure
3. Prolonged use
4. Application to large surfaces

Answer 10

Prolonged use

Application to large surfaces