Practice Exam Flashcards Preview

Pharm FINAL > Practice Exam > Flashcards

Flashcards in Practice Exam Deck (31):
1

Clorsulon is first effective against liver flukes at how many weeks post infection?

10 weeks

2

To treat his cattle for GI nematodes and liver flukes with a single drug, a rancher must use a drug that

Inhibits microtubule formation

3

Praziquantel (Droncit®) differs from epsiprantel (Cestex®) in that...

Praziquantel is highly absorbed in the patient GI tract, but epsiprantel is not.

4

During an initial well-check, you notice Strongylus spp. roundworm eggs in a fecal float from a Friesian horse that some reliable clients recently purchased. Which of the following drugs ARE labeled for the treatment of GI round worms in this horse?

Pyrantel pamoate (Strongid-T®)
Piperazine
Moxidectin (Quest®)
Ivermectin (Equimectrin®)

5

During an initial well-check, you notice Strongylus spp. roundworm eggs in a fecal float from a Friesian horse that some reliable clients recently purchased. Which of the following drugs ARE NOT labeled for the treatment of GI round worms in this horse?

Albendazole (Albenza®)

6

Piperazine
Mechanism of action?

Stimulation of GABA receptors

7


Regarding differences between albendazole (Albenza®) and fenbendazole (Safe-Guard®):

fenbendazole is indicated for use in dogs, cows, and horses, but among these, albendazole is only indicated for use in dogs and cows

8

Which of the following drugs is indicated for generalized demidocosis?

Amitraz (Mitaban®)

9

Which of the following drugs increases a hormone present in insect larvae that normally stimulates maturation when it declines?

Methoprene (in Bio Spot®)

10

Which of the following drugs causes repetitive depolarizations of Na+ channels in the nervous systems of insects?

Permethrin (in Advantix®)

11

Which of the following is are mechanisms by which the effect of ivermectin (Heartgard®) is prolonged?

Enterohepatic recycling
Lipophilic distribution to fat
Slow metabolism
Slow distribution from fat to plasma

12

Which of the following macrocyclic lactones is permitted for use in lactating dairy cattle?

Eprinomectin (Eprinex®)

13

In veterinary medicine, expression levels of P-glycoprotein are important for the..

toxic effects of ivermectin (Heartguard®) in Miniature Australian Shepherds.
resistance of Haemonchus contortus (GI roundworms) to albendazole (Valbazen®).
resistance of Haemonchus contortus (GI roundworms) to ivermectin (Ivomec®).
toxic effects of moxidectin (ProHeart 6®) in Silken Windhounds.

14

In veterinary medicine, expression levels of P-glycoprotein are NOT important for the:

toxic effects of milbemycin oxime (Interceptor®) in Longhaired Whippets.

15

A poultry farm is having an outbreak of coccidiosis. Which of the following drugs used to treat this disease competes with guanine metabolism in the parasites?

Robenidine

16

Tocerinib MOA?

inhibition of protein tyrosine kinases

17

Doxorubicin causes..

cumulative cardiotoxicity

18

What drugs are used in a CHOP protocol?

Doxorubicin
Prednisone
Vincristine
Cyclophosphamide

19

Following an amputation to remove a primary, osteosarcoma tumor, a Great Dane is started on a chemotherapic drug to slow the progression of lung metastases. This drug has the adverse side effect that it causes damage to accumulate in the patient's cardiomyocytes.  This drug may also cause:

severe tissue damage.

20

By comparison to albendazole, clorsulon

is effective against liver flukes at an earlier time following infection.

21

Injection site inflammation is a common side effect associated with which of the following anti-nematodal agents?

Melarsomine (Immiticide)

22

Imidocloprid acts by:

activation of nicotinic AChR’s.

23

A collie would be treated for two months with selemectin prior to melarsomine treatment for Class 2 heartworm disease, because:

it takes that long for developing adults to mature, while selamectin kills new larvae.

24

Macrocyclic lactones kill ectoparasites, because of:

irreversible activation of parasite GluCl receptors.

25

Selemectin differs from milbemycin oxime in that

milbemycin oxime does not penetrate the blood brain barrier, but selemectin does.

26

A calf presents with severe diarrhea and requires therapy.  Which of the following drugs is a treatment option?

Halofuginone

Amprolium

Decoquinate

Monensin

27

A Clydesdale presents with depression, lack of appetite, and anemia.  Further investigation reveals organisms in a blood smear that look very similar to those below, and are subsequently determined to be Babesia caballi.  The drug of choice acts by:

denaturing DNA.

28

In comparing ponazuril (Marquis) to diclazuril (Protozil):

diclazuril has no reported adverse effects, but ponazuril can cause seizures.

29

Which of the following treatments is most appropriate for a 13-year-old, spayed, female Miniature Doberman Pinscher that has been on cyclosporine for the last year and was just diagnosed with disseminated toxoplasmosis? Liver and renal laboratory values are within normal limits (WNL).

Clindamycin (Antirobe)

30

Masitinib (Masivet®) acts at which phase of the cell cycle?

G1

31

The drug of choice (or the one that is used in most protocols) for the treatment of transitional cell carcinomas:..

inhibits cyclooxygenase.