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Flashcards in Prelim drugs Deck (68):
1

Drug Name

Drug Class
Mechanism
Distinguishing Chem Characteristics (Unique or "weird" features)
Pharmacological characteristics
Side Effects
Special side effects
Use
[mnemonic] (put in brackets)

2

cyclophosphamide

-alkylating agents (bischoloroethyl amines)

3

mechlorethamine

-alkylating agents (bischoloroethyl amines)

4

nitrosureas

-alkylating agents

5

procarbazine

-alkylating agents (other)

6

cisplatin

-platinum coordination complexes

7

methotrexate

-anti-tumor antimetabolites

8

leucovorin

-anti-tumor antimetabolites (folinic acid rescue)

9

5-fluorouracil

-anti-tumor antimetabolites
-pyrimidine antagonist

10

capecitabine

-anti-tumor antimetabolites
-pyrimidine antagonist

11

cytosine arabinoside (cytarabine, ara C)

-anti-tumor antimetabolites
-pyrimidine antagonist

12

6-mercaptopurine

-anti-tumor antimetabolites
-purine antagonist

13

6-thioguanine

-anti-tumor antimetabolites
-purine antagonist

14

bleomycin

-anti-tumor antibiotics

15

daunorubicin

-anti-tumor antibiotics, topoisomerase inhibitors

16

doxorubicin

-anti-tumor antibiotics, topoisomerase inhibitors

17

paclitaxel

-mitotic spindle poisons

18

vinblastine

-mitotic spindle poisons (vinca alkaloids)

19

vincristine

-mitotic spindle poisons (vinca alkaloids)

20

irinotecan

-topoisomerase inhibitors (camptothecins)

21

topotecan

-topoisomerase inhibitors (camptothecins)

22

daunorubicin

-anti-tumor antibiotics, topoisomerase inhibitors

23

doxorubicin

-anti-tumor antibiotics, topoisomerase inhibitors

24

etoposide

-topoisomerase inhibitors

25

tamoxifen

-antagonist of hormone action

26

raloxifene

-antagonist of hormone action

27

anastrozole

-antagonist of hormone action

28

letrozole

-antagonist of hormone action

29

exemestane

-antagonist of hormone action

30

leuprolide

-antagonist of hormone action

31

flutamide

-antagonist of hormone action

32

prednisone

-adrenocorticosteroids

33

lapatinib

-"Targeted" agents (EGFR kinase inhibitors)

34

erlotinib

-"Targeted" agents (EGFR kinase inhibitors)

35

lapatinib

-"Targeted" agents (HER2 kinase inhibitor)

36

imatinib

-"Targeted" agents (bcr/abl kinase inhibitor)

37

cetuximab

-"Targeted" agents (chimeric/humanized antibodies)

38

trastuzumab

-"Targeted" agents (chimeric/humanized antibodies)

39

brentuximab vedotin

-"Targeted" agents (chimeric/humanized antibodies)

40

Drug Name

Drug Class
Mechanism
Distinguishing Chem Characteristics (Unique or "weird" features)
Pharmacological characteristics
Side Effects
Special side effects
Use
[mnemonic] (put in brackets)

41

Morphine

-Opioid agonist
-Mu receptor
-
-
-sedate, constipate, resp depress, nausea/vomit
-euphoria, miosis
-Analgesia

42

Drug Name

Drug Class
Mechanism
Distinguishing Chem Characteristics (Unique or "weird" features)
Pharmacological characteristics
Side Effects
Special side effects
Use
[mnemonic] (put in brackets)

43

amitriptyline

-tricyclics (TCA's)
-block ser & NE reuptake
-block histamine, muscarinic, adrenergic R's.
-2 weeks to work, long half-life, kidney elim & bit hepatic microsomes
-antimuscarinic, sedation (H1 R), sex down, weight up, delirium, tachycardia
-seizures, slowing A-V conductance, orthostatic hypotension (alpha 1 R)
-Antidepressant

44

amoxapine

-tricyclics (TCA's)
-block ser & NE reuptake
-block histamine, muscarinic, adrenergic R's.
-2 weeks to work, long half-life, kidney elim & bit hepatic microsomes
-antimuscarinic, sedation (H1 R), sex down, weight up, delirium, tachycardia
-seizures, slowing A-V conductance, orthostatic hypotension (alpha 1 R)
-Antidepressant

45

imipramine

-tricyclics (TCA's)
-block ser & NE reuptake
-block histamine, muscarinic, adrenergic R's.
-2 weeks to work, long half-life, kidney elim & bit hepatic microsomes
-antimuscarinic, sedation (H1 R), sex down, weight up, delirium, tachycardia
-seizures, slowing A-V conductance, orthostatic hypotension (alpha 1 R)
-Antidepressant

46

nortriptyline

-tricyclics (TCA's)
-block ser & NE reuptake
-block histamine, muscarinic, adrenergic R's.
-2 weeks to work, long half-life, kidney elim & bit hepatic microsomes
-antimuscarinic, sedation (H1 R), sex down, weight up, delirium, tachycardia
-seizures, slowing A-V conductance, orthostatic hypotension (alpha 1 R)
-Antidepressant

47

citalopram

-SSRI's
-block ser reuptake
-neurogenesis in hippocampus (via BDNF)
-2 wks to work, kidney elim, block P450, high first-pass effect, binds plasma proteins
-nausea, anxiety, insomnia... late: sex down
-late: anorexia, mania
-Antidepressant

48

escitalopram

-SSRI's
-block ser reuptake
-neurogenesis in hippocampus (via BDNF)
-2 wks to work, kidney elim, block P450, high first-pass effect, binds plasma proteins
-nausea, anxiety, insomnia... late: sex down
-late: anorexia, mania
-Antidepressant

49

fluoxetine

-SSRI's
-block ser reuptake
-neurogenesis in hippocampus (via BDNF)
-demethylated to active. 2 wks to work, kidney elim, block P450, high first-pass effect, binds plasma proteins
-nausea, anxiety, insomnia... late: sex down
-late: anorexia, mania
-Antidepressant

50

sertraline

-SSRI's
-block ser reuptake
-neurogenesis in hippocampus (via BDNF)
-2 wks to work, kidney elim, block P450, high first-pass effect, binds plasma proteins
-nausea, anxiety, insomnia... late: sex down
-late: anorexia, mania
-Antidepressant

51

duloxetine

-SNRI's
-block ser, NE reuptake (but UNRELATED to TCA's)
-
-1/4 bound to plasma proteins, elim mostly kidney. metab by CYP1A2, CYP2D6
-nausea, anxiety, insomnia, sex down [same as SSRI's!]
-high dose up blood pressure
-depression refractory to SSRI's

52

venlafaxine

-SNRI's
-block ser, NE reuptake (but UNRELATED to TCA's)
-
-mostly bound to plasma proteins, elim mostly kidney. metab by CYP2D6
-nausea, anxiety, insomnia, sex down [same as SSRI's!]
-high dose up blood pressure
-depression refractory to SSRI's

53

bupropion

-atypicals

54

mirtazapine

-atypicals

55

nefazodone

-atypicals

56

phenelzine

-MAOi's

57

selegiline

-MAOi's

58

tranylcypromine

-MAOi's

59

lithium

-bipolar treatment

60

carbamazepine

-bipolar treatment

61

olanzapine

-bipolar treatment

62

risperidone

-bipolar treatment

63

valproic acid

-bipolar treatment

64

amphetamine

-Stimulants

65

atomoxetine

-Stimulants

66

dextro-amphetamine

-Stimulants

67

methylphenidate

-Stimulants

68

modafinil

-Stimulants