Flashcards in principles of endocrinology Deck (17):
what type of signaling is when hormones are synthesized by endocrine cells and are secreted into blood stream and have their systemic effects
which hormone circulates in free form and binds to surface receptors?
which hormones are derived from cholesterol
which hormones bind to intracellular receptors
which hormone is derived from tyrosine?
amino acid hormones
what are peptide hormones composed of
multiple amino acids
what do amino acid horomones produce
catecholamine and thyroid hormones
which hormones have longer 1/2 life? why?
lipophilic hormones have longer half life than water soluble, because lipophilic hormones bind to plasma protein which increase 1/2 life.
the more plasma protein binding, the longer the 1/2 life
What mechanisms regulates the hormone release?
neural, hormonal, nutrient/ion regulation
what are the causes of endocrine dysfunction?
too much or too little hormone action, decreased responsive ness, decreased sensitivity
if you have high pituitary hormone level and low target hormone level, the cause is?
failure of target organ
if you have low pit, hormone level and low target hormone level.. it's due to?
High pituitary hormone level and high target hormone level
autonomous secretion of pituitary hormone or resistance to target hormone action.
neg feedback not working due to defect on pituitary, or if target organ is not responding to hormone will cause pituitary to produce more
Low pituitary hormone level and high target hormone level
autonomous secretion by target endocrine organ
Physiological "add back"
supplement hormone if lack endogenous hormones, ie hypogonadism
oral glucose to test insulin release