Pro-Inflammatory Cytokines Flashcards
(18 cards)
What are the pro-inflammatory cytokines
TNF-a, IFN-y, IL1, IL6, IL8, IL11, IL12, IL15, IL18
What cells secrete TNF-a?
M#, NK, Tcell
What cells secrete IFN-y?
NK, T cells
**The only cytokine NOT produced by M#’s****
What cells secrete IL-1
MEHKDCFB
M#, Endothelial Cells, Hepatocytes, Keratinocytes, DCs, Fibroblasts
What cells secrete IL-6
6 LBs of MEaT
M#, Endothelial cells, T cells
What cells secrete IL-8
MET 8 FB Players with New Active Chemo
M#, Endothelial cells, T cells, Fibroblasts, Platelets
What cells secrete IL-11
I haven’t found anywhere that answers that
What cells secrete IL-12
12 TaNKs in THe1 Different Deacon’sCuorum
M#, DCs
What cells secrete IL-15
Max the 15yo TaNK Pro Remembers the 8 yo’s T cell Chemo
M#
What cells secrete IL-18
Max will TaNK if he Syns at age 18
M#
What does TNF-a secretion lead to?
HELNCO Hypothalamus = Fever Endothelium = inflammation and coagulation Liver = increased acute phase proteins Neutrophils = activation Cachexia = Muscle & Fat Other = apoptosis
What does IFN-y secretion lead to?
10X increase in M#; increased Abs.
What does IL1 secretion lead to?
MEHKDCFB = HEL1 Hypothalamus = Fever Endothelium = inflammation and coagulation Liver = Increased APPs
What does IL6 secretion lead to?
6 LBs of MEaT
Liver = increased APPs
B cell = increased Ab-producing cells
What does IL8 secretion lead to?
MET 8 FB Players with New Active Chemo
Activation and Chemotaxis of Neutrophils
or Clean up on IL-8 = IL8 recruitment of neuts. to clear infx.
What does IL12 secretion lead to?
12 TaNKs IN THe 1 Different Deacon’sCuorum
- *Increased IFN-y; TH1 differentiation
- *Synergizes with IL18 –> Increased IFN-y
What does IL15 secretion lead to?
Max the 15 yo TaNK Pro Remembers his 8 yo T cell Chemo
- *T cell and NK proliferation
- *CD8 memory cells
- Chemotactic for T cells
What does IL18 secretion lead to?
Max will TaNK IF Syn when 18
T cell and NK cell lead to IFN-y synthesis
