Flashcards in Progestins, Estrogens, & Androgens Deck (50)
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31
What is the only antagonist of CV system SERM?
clomiphen/fluvestrant
32
What SERMS are antagonistic to the endometrium? neutral?
1. clomiphene/fluvestrant & bazedoxifene
2. raloxifene and ospemifene
33
What is the only antagonist to vaginal epithelium SERM? neutral?
1. clomiphene fluvestrant
2. raloxifene
34
What is roloxifenes big advantage over tamoxifen?
not being an agonist in endometrium
35
When given early in the menstrual cycle what do the clomiphene and fulvestrants do?
induce ovulation- antagonize the inhibitory effects of estrogen on the pituitary and hypothalamus
36
What are aromatase inhibitors useful for? can they be steroidal or non-steroidal?
1. treat breast cancer and induce ovulation
2. Both
37
What can RU486 be used for other than abortion?
glucocorticoid antagonist and is
approved to be used as such in the treatment of
individuals with Cushing’s and type 2 diabetes
38
What does LH and FSH increase in the testes? Do they feedback inhibit the HPA axis?
1. Androgens (testosterone and dihydrotestosterone)
2. Yes
39
What cells ini the testes form testosterone and estradiol?
leydig cells
40
What takes cholesterol to pregenelone? what takes testosterone to estradiol? what takes testosterone to dihydrotestosterone?
1. cholesterol side chain cleavage
2. aromatase
3. 5 alpha-reductase
41
Review the following actions of androgens
1. Virilization of the urogenital tract during development
2. puberty
3. maintenance of secondary sexual characteristics
4. essential for spermatogenesis
5. promote anabolic reactions
42
Testosterone is ineffective when given orally, how
can it be administered?
transdermally (ANDROGEL®) or as
buccal tablets (STRIANT®).
43
How can testosterone esters be given?
intramuscularly
44
What can be given orally that is an analog of testosterone? what is the problem though?
17 alpha alkylated androgen (danazole)
but they have more side effects such as liver toxicity
45
What is androgen therapy used for?
Replacement therapy in male hypogonadism
treatment of some catabolic states such as muscle wasting
46
REview the side effects of androgen therapy
Virilization, feminization, suppression of HPA, edema, jaundice, hepatic carcinoma
47
What do we screen for ovulation? pregnancy?
LH
CG
48
What do we use FSH for? CG for?
Induce follicular growth
induce ovulation
BOTH ARE INJECTIONS
49
gonadorelin in a synthetic GnRH that does what?
stimulates gonatotropin secretion
50
