Progestins, Estrogens, & Androgens Flashcards Preview

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Flashcards in Progestins, Estrogens, & Androgens Deck (50)
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31

What is the only antagonist of CV system SERM?

clomiphen/fluvestrant

32

What SERMS are antagonistic to the endometrium? neutral?

1. clomiphene/fluvestrant & bazedoxifene
2. raloxifene and ospemifene

33

What is the only antagonist to vaginal epithelium SERM? neutral?

1. clomiphene fluvestrant
2. raloxifene

34

What is roloxifenes big advantage over tamoxifen?

not being an agonist in endometrium

35

When given early in the menstrual cycle what do the clomiphene and fulvestrants do?

induce ovulation- antagonize the inhibitory effects of estrogen on the pituitary and hypothalamus

36

What are aromatase inhibitors useful for? can they be steroidal or non-steroidal?

1. treat breast cancer and induce ovulation
2. Both

37

What can RU486 be used for other than abortion?

glucocorticoid antagonist and is
approved to be used as such in the treatment of
individuals with Cushing’s and type 2 diabetes

38

What does LH and FSH increase in the testes? Do they feedback inhibit the HPA axis?

1. Androgens (testosterone and dihydrotestosterone)
2. Yes

39

What cells ini the testes form testosterone and estradiol?

leydig cells

40

What takes cholesterol to pregenelone? what takes testosterone to estradiol? what takes testosterone to dihydrotestosterone?

1. cholesterol side chain cleavage
2. aromatase
3. 5 alpha-reductase

41

Review the following actions of androgens

1. Virilization of the urogenital tract during development
2. puberty
3. maintenance of secondary sexual characteristics
4. essential for spermatogenesis
5. promote anabolic reactions

42

Testosterone is ineffective when given orally, how
can it be administered?

transdermally (ANDROGEL®) or as
buccal tablets (STRIANT®).

43

How can testosterone esters be given?

intramuscularly

44

What can be given orally that is an analog of testosterone? what is the problem though?

17 alpha alkylated androgen (danazole)

but they have more side effects such as liver toxicity

45

What is androgen therapy used for?

Replacement therapy in male hypogonadism

treatment of some catabolic states such as muscle wasting

46

REview the side effects of androgen therapy

Virilization, feminization, suppression of HPA, edema, jaundice, hepatic carcinoma

47

What do we screen for ovulation? pregnancy?

LH
CG

48

What do we use FSH for? CG for?

Induce follicular growth
induce ovulation

BOTH ARE INJECTIONS

49

gonadorelin in a synthetic GnRH that does what?

stimulates gonatotropin secretion

50

What does luprolide do?

– After and initial stimulation of gonadotropin secretion they
suppress it (desensitization).
– Therefore these are used to suppress gonadotropin
secretion (like GnRH antagonists). Injectable