Progression of AD Flashcards Preview

Alzheimers Disease > Progression of AD > Flashcards

Flashcards in Progression of AD Deck (13):
1

Preclinical AD is characterized by...
1. first signs are noticed int he ________ cortex, then proceed to the _________
2.affected regions begin to shrink as nerve cells die
3.Levels of _______ particularly ____ drop.
4.Changes can begin ___ to ____ years before symptoms appear.
5. _______is the first sign of AD

Preclinical AD is characterized by...
1. first signs are noticed in the ENTORHINEAL cortex, then proceed to the HIPPOCAMPUS
2.affected regions begin to shrink as nerve cells die
3.Levels of NEUROTRANSMITTER particularly ACETYLCHOLINE drop.
4.Changes can begin 10 to 20 years before symptoms appear.
5. MEMORY LOSS is the first sign of AD

2

First measurable signs of AD occur in the .... and proceed to the .....

entorhineal cortex and proceed to the hippocampus

3

During mild to moderate AD...

cortex begins to shrink due to neuronal loss

4

Symptoms of mild AD include...
(6)
1 MMMAP

memory loss, confusion, trouble handling money, poor judgement, mood changes and anxiety

Memory, Mood, Money, anxiety, poor judgment

5

Moderate AD symptoms...
MMAP + ...

increased memory loss, confusion, problems recognizing people, difficulty with language and thoughts, restlessness, agitation, wandering and repetitive statements.

memory, mood, money, anxiety poor judgment, diff recognizing people , use language, thoughts and restlessness, repetitive statements and wandering.

6

Severe AD progression...

extreme shrinkage occurs in the brain, and patients are completely dependent on others

7

Symptoms of severe AD...

weight loss, seizures, skin infections, groaning, moaning, or grunting, increased sleeping, loss of bladder control and bowel movements.

8

How does death usually occur

aspiration pneumonia or other infections

9

AD likely caused by interplay of ...

genetic, environmental and lifestyle factors

10

Free radicals are...and the _____ damage from them can...Resistance to and ______ of this damage ...

by products of normal metabolism and the oxidative damage from them can injure molecules. Resistance and repair of this damage declines with age

11

Free radicals are inhibited by...

antioxidants

12

In early life higher skills in ..... and density of _______ are associated with protection from AD

In early life higher skills in grammar and density of ideas are associated with protection from AD

13

Physicians use the following to diagnose AD:
1. detailed...
2.info from...
3.___ &____ exams and _____ tests
4.neuropsychological tests
5.imaging tools such as.....

1. detailed patient history
2.info from family & friends
3. physical & neurological exams and lab tests
4.neuropsychological tests
5.imaging tools such as CT and MRI- PET more for research purposes