Prostaglandins and Eicosanoids Flashcards Preview

Topnotch Pharmacology (Sept 2017) > Prostaglandins and Eicosanoids > Flashcards

Flashcards in Prostaglandins and Eicosanoids Deck (20):
1

Eicosanoids are derived from?

Arachidonic acis

2

Eicosanoid: vascular smooth muscle relaxation, protective effects on gastric mucosa, maintains PDA

PGE1

3

Eicosanoid: vascular smooth muscle relaxation, maintains PDA, increases uterine tone

PGE2

4

Eicosanoid: vascular smooth muscle relaxation,(peripheral,pulmonary, coronary)

PGI2

5

Increases uterine tone, decreases IOP

PGF2a

6

Activates EP receptors, causes increased HCO3 and mucus secretion in stomach, uterine contraction

Misoprostol

7

Indicated for PUD ,prevention of nsaid induced gastric mucosal injury

Misoprostol

8

SE: moebius sequence

Misoprostol

9

Activates EP receptors , causes vascular smooth muscle relaxation and vasodilation; indicated for maintenance of PDA and erectile dysfunction

Alprostadil

10

Eicosanoids include:

Leukotrienes, Prostacyclin, Prostaglandin, Thromboxane

11

Eicosanoid family that is straight chain

Leukotrienes

12

Prostaglandin E1 analogues

Misoprotol, alprostadil

13

Prostaglandin E2 analog

Dinoprostone

14

Prostaglandin F2a analog

Carboprost, latanoprost

15

Prostaglandin I2 analog

Epoprostenol

16

Eicosanoid: Low concentrations contract, higher concentration relax uterine and cervical smooth muscle

Dinoprostone

17

Control of postpartum hemorrhage

Carboprost

18

Pulmonary hypertension, reduces platelet aggregation in dialysis mahines

Epoprostenol

19

Glacuoma

Latanoprost

20

Permanent eye color change

Latanoproet