Prostaglandins and other Eicosanoids Flashcards Preview

P Pha T > Prostaglandins and other Eicosanoids > Flashcards

Flashcards in Prostaglandins and other Eicosanoids Deck (11):
1

Leukotriene components of the slow-reacting substance of anaphylaxis (mediators of bronchial asthma): (2)

LTC4, LTD4

2

A leukotriene chemotactic factor

LTB4

3

With protective effects on gastric mucosa (can increase secretion of mucus and bicarbonate); maintains patent ductus arteriosus

PGE1

4

Increases uterine tone; maintains patent ductus arteriosus

PGE2

5

For vascular smooth muscle relaxation (peripheral , pulmonary, coronary)

PGI2 (prostacyclin)

6

Decreases intraocular pressure; increases uterine tone

PGF2alpha

7

For platelet aggregation

TXA2 (thromboxane A2)

8

A prostaglandin E1 analog used for erectile dysfunction (injected directly to the cavernosa) and for the maintenance of patent ductus arteriosus

Alprostadil

9

Prostaglandin E2 analog used for induction of labor (cervical ripening). Low concentrations contract, higher concentration relax uterine and cervical smooth muscle.

Dinoprostone
SimD: Sulprostone

10

Prostaglandin I2 analog used for pulmonary hypertension and for reduction of platelet aggregation in dialysis machines

Epoprostenol

11

Prostaglandin F2alpha analog which is the drug of choice for glaucoma. It increases the outflow of aqueous humor and reduces intraocular pressure. Side effects include alteration of the iris, causing permanent color change. It also lengthens the eyelashes.

Latanoprost

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