Flashcards in Proteins Deck (32):
What are 3 examples of proteins?
What is an enzyme-like function?
Amelogenin acting as a scaffold for the mineralization of enamel
What is the typical composition of bone?
Mineral (Hydroxyapatite 50-70%)
Protein (Mostly collagen; 20-40%)
Non-collagen proteins (typically 1-2%)
The linkage between amino acids in protein is an _____ linkage?
Two amino acids hooked together is a ______ bond
Most proteins are ___ - ______ amino acids long
50 - 2000
Each protein sequence produces its own _______
specifies protein backbone dihedral angle
Rotation around the peptide bond is restricted by ________. This simplifies deducing secondary structures.
Spiral staircases with amino acid steps
How many steps per alpha helice turn?
What handed are alpha-helices?
How do side chains project on alpha helices?
up and out
What is the distance between
What is the distance between neighboring B strand residues?
How do beta strands pair?
B-strands are fully ______ conformations
B - strands can align both _______ and ______ to form B- sheets
Silk fibroin is all __ sheet
Amyloid of _______ disease is almost all __ sheet
__ - keratin (intracellular fibers of skin) is all __ helix (coiled-coil)
Myosin (protein for muscle contraction) is mostly __ helix
Some _______ - forming proteins are disordered before forming amyloid
starch like but is actually a protein, presence in almost all neurogenerative diseases
Parallel B-sheet can wrap as a helix __ - helix
The collagen triple helix is 1/3 _____.
The collagen triple helix has inter-helical -bonds
What is the hydrogen bond donor of the collagen triple helix?
NH2 of glycine
What is the three dimensional structure of the polypeptide chain stabilized by?
hydrogen bonds, electrostatic and hydrophobic interactions and certain cases by disulfide linkage between cysteine residues
refers to the arrangement of protein subunits in a multinumeric complex
What is one of the most well known and highly characterized multi-protein complexes?