Proteins And Peptide

Question 1

What is the process to peptide synthesis in the lab?

Answer 1

Protecting of amino acid residues with protecting groups

Condensation of the two protected amino acids to form peptide bond

Removal of protecting groups

Question 2

What is the angle called between C-N and C-C

Answer 2

C-N phi

C-C psi

Question 3

Are steric clashes favourable?

Answer 3

No

Question 4

Why is glycine, cysteine and proline different?

Answer 4

Glycine - no chiral centre

Cysteine -thiol group

Proline - secondary amine

Question 5

What is structural motif and protein domain?

Answer 5

Motif - groupings of secondary structure elements

Protein domain: multiple domains

Question 6

What are the two important consequences of the resonance stabilisation of the amide group?

Answer 6

Peptide bond chemically inert

Amide group is planar