Prototype Drug Unit 5 & 7- Amantadine

Question 1

Therapeutic classification

Answer 1

Antiviral for influenza

Question 2

Pharmacologic classification

Answer 2

Viral replication inhibitor

Question 3

Therapeutic effects and uses

Answer 3

Primary use is for influenza

Question 4

Mechanism of action

Answer 4

Not known, but thought to inhibit viral replication by preventing uncoating

Question 5

Adverse effects

Answer 5

Nausea, dizziness, nervousness, difficulty concentrating, insomnia

Question 6

Contraindications

Answer 6

CNS disease, suicidal ideation, psychiatric disorders. Renal impairment, cardiac disease. Should not be abruptly stopped in Parkinson’s disease patients

Question 7

Drug interactions

Answer 7

Alcohol, Anticholinergic drugs, Dopamine antagonists, Trimethoprim-sulfamethoxazle

Question 8

Treatment of overdose

Answer 8

Physostigmine to control CNS symptoms and anticonulsants if necessary. Acidic drugs enhances renal excretion. Antidysrhythmics and antihypertensives may be administered to manage cardiovascular toxicity