Prototype Drug Unit 5 & 7- Interferon Alfa-2b (Intron A) Flashcards

1
Q

Therapeutic classfication

A

Immunostimulant

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2
Q

Pharmacologic classification

A

Interferon, biologic response modifier

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3
Q

Therapeutic effects and uses

A

Used for conditions like hairy cell leukemia, malignant melanoma, non-Hodgkin’s lymphoma, and AIDS-related Kaposis sarcoma and viral infections. Also used for chronic myelogenous leukemia, bladder cancer, herpes simplex virus, multiple myeloma, renal cell cancer, HIV, VZV, and West Nile Virus

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4
Q

Mechanism of action

A

First: enhances the general functions of the immune system
Second: The drug suppresses the growth of cancer cells

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5
Q

Adverse effects

A

Flulike syndrome of fever, chills, dizziness, weight loss, and fatigue. These symptoms can diminish as therapy progresses

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6
Q

Black Box Warning

A

IFNs may cause or aggravate fatal or life-threatening neuropsychiatric, autoimmune, ischemic, or infectious disorders.

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7
Q

Contraindications/precautions

A

Neonates and infants because it contains benzyl alcohol. If infection occurs during therapy, antiinfectives should be started immedicately

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8
Q

Drug interactions

A

Increases theophylline levels. Zidovudine may increase hematologic toxicity and cause immunosuppression

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