Flashcards in PSL301: Cardio 8 Deck (44):
1
Pc
capillary hydrostatic pressure
2
Pif
interstitial fluid pressure
3
(pi)c
plasma colloid osmotic pressure
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(pi)if
Interstitial fluid colloid pressure
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Define: Pc
move fluid out
due to fluid pressure in blood
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Define: Pif
move fluid in
Opposes outward movement of Pc
due to fluid pressure in ISF
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Define: (pi)c
Move fluid in
if proteins in blood > proteins in ISF
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Define: (pi)if
Move fluid out
if proteins in ISF > proteins in blood
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Formula: net fluid pressure (at capillaries)
Fluid out - fluid in
[Pc + (pi)if] - [Pif + (pi)c]
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Value: Pif
why?
- 3 mmHg
Lymphatic system remove fluid
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Value: Pc
45 to 10 mmHg
12
Value: (pi)if
why?
8 mmHg
Lympathic system remove proteins
13
Value: (pi)c
28 mmHg
14
Value: plasma protein concentration
7.3 mg/dl
15
What makes up the plasma proteins?
75% albumin
25% globulin
Very little fibrinogen
16
Value: interstitial protein concentration
3 mg/dl
17
If net fluid pressure is positive...
More fluid going out of vessel
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If net fluid pressure is negative...
More fluid going into vessel
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Due to the gradient from Pc, __L of net flow outward per day
3L
20
Forces that push fluid out of vessels
1. Hydrostatic pressure
2. Pressure from LACK OF fluid in ISF
3. Interstitial colloid osmotic pressure
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Forces that push fluid into vessels
1. plasma colloid osmotic pressure
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Value: mean hydrostatic pressure
17.3 mmHg
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Value: filtration coefficient
10 mL/min/mmHg
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Formula: filtration rate
filtration coefficient * net filtration pressure
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Value: net filtration rate
3 mL/min
that much fluid is deposited in ISF every minute
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Functions of lympathic system
1. Return fluid & proteins to circulatory system
2. Pick up fat from intestines and deliver to circulatory system
3. Help trap pathogens
27
Lymphatic system help prevent...
edema
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Lymph is derived from...
ISF
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Where does the lymphatic system drain into?
subclavian veins
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What determines lymph flow?
1. Valves
2. External compression (skeletal pump)
3. Smooth muscle in lymph vessel
4. Pif
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What if flow in lymphatic system is blocked?
Edema
32
3 factors that might cause edema
1. Increase hydrostatic pressure
2. Decrease in plasma protein
3. Increase in interstitial proteins
33
Where does edema happen?
any vascularized tissue
34
One specific edema disease is...
Elephantiasis
35
What causes elephantiasis?
small parasitic roundworms
36
What is the vector for elephantiasis?
Mosquitos
37
Define: elephantiasis
abnormal enlargement of any part of the body due to obstruction of the lymphatic channels in the area
38
Fluid accumulation in the abdomen is called...
Ascites
39
Ascites
Accumulation of fluid in the abdomen
40
Another name for abdomin
peritoneal cavity
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Disease of ascites
Kwashiorkor: lack of protein in diet
Liver cirrhosis: cannot produce enough albumin
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What may cause liver cirrhosis?
Alcoholism
Hepatitis
Fatty liver disease
Acetaminophen
43
CVD includes...
1. CHD
2. Cerebrovascular disease
3. Peripheral arterial disease
4. Rheumatic heart disease
5. Congenital heart disease
6. Deep vein thrombosis & pulmonary embolism
44