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Board Review - B - Systems Pharmacology > Psych II > Flashcards

Flashcards in Psych II Deck (38)
1

fluoxetine

SSRI

2

paroxetine

SSRI

3

sertraline

SSRI

4

citalopram

SSRI

5

SSRIs

5-HT specific reuptake inhibitors

6

clinical use SSRI

depression
GAD
panic disorder
OCD
bulimia
social phobia
PTSD

7

SSRI time to take effect

4-8 weeks

8

serotonin syndrome

any drug increased 5-HT
-SNRI, MAOI, SSRI, TCA

hyperthermia, confusion, myoclonus, CV instability, flushing, diarrhea, seizures

tx - cyproheptadine

9

cyproheptadine

5-HT2 receptor antagonist

tx serotonin syndrome

10

venalfaxine

SNRI

11

duloxetine

SNRI

12

SNRI

inhibit 5-HT and NE reuptake

13

clinical use SNRI

depression

venlafaxine - GAD, panic disorder, PTSD
duloxetine - diabetic peripheral neuropathy

14

amitriptyline

TCA antidepressant

15

nortriptyline

TCA antidepressant

16

imipramine

TCA antidepressant

17

desipramine

TCA antidepressant

18

clomipramine

TCA antidepressant

19

doxepin

TCA antidepressant

20

amoxapine

TCA antidepressant

21

TCA antidepressant

block reuptake of NE and 5-HT

22

3rd vs. 2nd degree TCA

amitriptyline - 3rd
nortriptyline - 2nd

3rd - more anticholinergic effect - prolong QT interval

23

Tri-Cs

adverse of TCA antidepressants

convulsions
coma
cardiotoxicity

24

tx TCA toxicity

NaHCO3 - prevent arrhythmia

25

tranylcypromine

monoamine oxidase inhibitor

26

phenelzine

monoamine oxidase inhibitor

27

isocarboxazid

monoamine oxidase inhibitor

28

selegiline

monoamine oxidase inhibitor - selective MAO-B

29

MAO inhibitors

nonselective MAO inhibition
-increased level of amine NTs
-NE, 5-HT, DA

30

clinical use MAOIs

atypical depression

31

ingestion of tyramine

wine and cheese - rich foods

toxicity with MAOIs
-get HTN crisis

32

CI for MAOI use

use of SSRI, TCA, dextromethorphan
-prevent serotonin syndrome

33

bupropion

atypical antidepressant

increase NE and DA - unknown mechanism

34

smoking cessation

bupropion

35

no sexual side effects

bupropion

36

mirtazapine

atypical antidepressant
a2 agonist - increased release of NE and 5-HT
-potent 5-HT2 and 5-HT3 receptor antagonists

37

trazadone

atypical antidepressant
block 5-HT2 and a1 receptors
-tx of insomnia

high dose - for antidepressant effect

38

erection side effect

trazadone
trazaBONER