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Flashcards in psych: pharmacokinetics, dosages, adverse reactions Deck (45):
1

 

 

phenothiazine adverse reactions

 

  • CV: dizziness, fainting, ortho hypotension, tachycardia
  • DERM: photosensitivity
  • EENT: blurry vision, increased IOP, mydriasis, retinal pigmentation
  • ENDO: hyperglycemia, weight gain, impaired thermoregulation
  • GI: dry mouth, constipation, jaundice
  • GU: decreased libido, decreased ejaculation, urinary retention
  • NEURO: EPS, impaired memory

2

 

 

phenothiazines pharmacokinetics

 

 

page 271

3

 

 

phenothiazine dosages

 

 

page 271

4

 

 

atypical antipsychotic pharmacokinetics

 

 

page 273

5

 

 

atypical antipsychotic dosages

 

 

page 273

6

 

 

atypical antipsychotic adverse reactions

  • CV: Risperdal causes dose related hypotension and reflex tachycardia; clozapine causes ortho hypotension, tachycardia, and myocarditis; quetiapine causes palpitations and postural hypotension
  • GI: N/V
  • GU: sexual dysfunction (risperidone)
  • HEM: clozapine (agranulocytosis)
  • MISC: weight gain, hypersalivation (clozapine); risperidone may effect sleep
  • NEURO: headache, insomnia, dizziness, akinesia, somnolence, EPS, NMS
    •  

7

 

 

MAOIs pharmacokinetics

 

 

page 277

8

 

 

MAOI dosages

 

 

page 277

9

 

 

MAOI adverse reactions

 

  • EENT: dilated pupils
  • GU: sexual dysfunction
  • NEURO: HYN crisis, serotonin syndrome
  • MISC: weight gain

10

 

 

TCA pharmicokinetics

 

 

page 278

11

 

 

TCA dosages

 

 

page 278

12

 

 

adverse reactions of TCAs

 

 

page 278

13

 

 

SSRI pharmacokinetics

 

 

page 280

14

 

 

SSRI dosages

 

 

page 280

15

 

 

SSRI adverse reactions

 

  • GI, nausea, diarrhea
  • GU: anorgasmia in men and women and ejaculatory disturbances in men
  • NEURO: agitation, headache, insomnia, nervousness, sedation, tremor, SEROTONIN SYNDROME

16

 

 

SNRIs pharmacokinetics

 

 

page 281

17

 

 

SNRI dosages

 

 

page 281

18

 

 

SNRI adverse reactions

  • CV: increase of 10-15 inDBP, diaphoresis
  • DERM: increased sweating, pruritus, rash
  • EENT: blurred vision, increased IOP
  • GI: nausea, dry mouth, constipation, anorexia, increased liver enzymes
  • GU: ejaculatory disturbances, erectile dysfunction, decreased libido, urinary hesitation
  • NEURO: tremor, seziures, fatigue, drowsiness, insomnia, headache

19

 

 

wellbutrin pharmacokinetics

 

 

page 282

20

 

 

wellbutrin dosages

 

 

page 282

21

 

 

clinical uses of wellbutrin asie from depression

 

  • smoking cessation (Zyban only)
  • off label treatment of adult ADHD
  • short term management of anxiety
  • increase sexual desire in women

22

 

 

trazadone pharmacokinetics

 

 

page 283

23

 

 

trazadone dosing

 

 

page 283

24

 

 

trazadone adverse reactions

 

 

  • CV: ortho hypotension for 4-6 hours after dose
  • GI: mild n/v
  • GU: priapism
  • NEURO: drowsiness

25

 

 

remeron pharmacokinetics

 

 

page 283

26

 

 

remeron dosing

 

 

page 283

27

 

 

remeron adverse reaction

 

  • GI: weight gain, dry mouth, increased appetite, n/v
  • MISC: flu-likesymptoms and abnormal dreams
  • NEURO: sedation

28

 

 

lithium pharmacokinetics

 

 

page 284

29

 

 

lithium dosing

 

 

page 285

30

 

 

lithium adverse reactions

 

 

page 285

31

 

 

dosing of depakote

 

 

page 286

32

 

 

depakote adverse reactions

 

  • SERIOUS: severe hepatic and pancreatic toxicity and thrombocytopenia
  • LESSER: weight gain, transient alopecia, drowsiness, nausea, abdominal pain, agitation, dizziness, headache, rashes, irregular meses, and tremors

33

 

 

uses of carbamazepine (Tegretol)

 

 

anticonvulsant

antimanic

antineuralgic

antipsychotic

34

 

 

tegretol mechanism of action

 

 

decreases sodium and calcium ion influx into neuronal membranes, thus reducing their potnetiation ability

35

 

 

abrupt withdrawal of tegretol may cause

 

 

status epilepticus

36

 

 

labs that must be monitored with Tegretol

 

 

CBC (aplastic anemia)

LFTs

serum drug levels

37

 

 

what is the last resort anxiolytic agent

 

 

tegretol

38

 

 

typical antipsychotics used to treat bipolaar mania

 

 

Zyprexa

Abilify

39

 

 

agents used to treat anxiety disorders

 

benzodiazepines

 

40

 

 

when are benzo's particularly useful

 

 

acute situation anxiety and adjustment disorder where therapy is expected to be less than 6 weeks

41

 

 

benzo mechanism of action

 

 

depress all levels of the CNS by enhancing the action GABA

enhanced GABA decreases neuronal excitation, thereby causing the anxiolytic effect

42

 

 

clinical uses of benzos

 

 

anxiety

anticonculsant

muscle relaxer

adjuvant for anethsethia

treatment of alcohol addiction and withdrawal

43

 

 

example of benzos

alprazolam (Xanax)

chlordiazepoxide (Librium)

clonazepam (Klonopin)

clorazepate (Tranxene ER)

diazepam (Valium)

lorazepam (Ativan)

oxazepam (Serax)

triazolam (Halcion)

44

 

 

benzo adverse reactions

 

 

page 288

45