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Flashcards in Psych Random Facts Deck (27):
1

NT in anxiety

Increased norepi, decreased GABA, decreased serotonin

2

NT in depression

Decreased norepi, serotonin, and dopamine

3

NT in Huntington's

Decreased GABA, decreased ACh, increased dopamine

4

NT in Parkinson's

Decreased dopamine, increased ACh

5

NT in Scizophrenia

Increased dopamine

6

Sleep changes in depression

Decreased slow wave sleep, Decreased REM latency, increased rem early in sleep cycle, increased total rem, early morning weakening. Repeated nighttime awakenings

7

NT in Alzheimer's

Decreased Ach, increased glutamate

8

When do sleep terrors occur?

During slow wave sleep (non-REM)

9

Electrolyte abnormality in refreshing syndrome

Hypophosphotemia, hypomagnesemia

10

Cause of narcolepsy

Decreased hypocretin (orexin) production in lateral hypothalamus

11

Treatment for cocaine intoxication

Alpha-blockers, benzodiazepines. Beta-blockers not recommended

12

MOA of varenicline

Partial agonist of nicotinic ACh receptor. Reduces nicotine withdrawal, prevents nicotine from binding and inducing reward response

13

MOA of PCP

NMDA receptor antagonist

14

MOA of naltrexone

Blocks the mu-opioid receptor, blocks the rewarding and reinforcing effects of alcohol-> reduces cravings

15

What can you use venlafaxine for?

PTSD, panic disorder

16

Pharmacology for Tourette syndrome

Antipsychotic (fluphenazine, pimozide), tetrabenazine, clonidine

17

High potency antipsychotics

Haloperidol, trifluoperazine, fluphenazine

18

What effect does blocking D2 receptors have?

Increases cAMP

19

Tx for EPS

Benztropine or diphenhydramine

20

SE of chlorpromazine

Antichiolinergic, antihistamine, and anti-alpha 1 adrenergic PLUS corneal deposits

21

SE of thioridazine

Antichiolinergic, antihistamine, and anti-alpha 1 adrenergic PLUS retinal deposits

22

What cardio effect might typical and atypical antipsychotics have

Prolong the QT interval

23

What medications may cause lithium toxicity?

Thiazides, NSAIDS, and ACE inhibitors

24

MOA of buspirone

Stimulates 5-HT1A receptors

25

Tx of serotonin syndrome

Cyproheptadine (5HT2 receptor antagonist)

26

Most common side effect of SNRIs

Increased blood pressure

27

MOA of mirtazapine

Alpha-2-antagonist (increases release of norepi and serotonin) and potent 5-HT2 and 5-HT3 receptor antagonist