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MS2 - Nervous System > Psychotic Disorders > Flashcards

Flashcards in Psychotic Disorders Deck (12):
1

What is the monozygotic twin concordance rate for schizophrenia?

60% - 80%

2

At what age does schizophrenia usually present?

18 - 25 (earlier in men)

3

What did the first neuroanatomical comparison between schizophrenic and non-schizophrenic brains show?

That those with schizophrenia have larger lateral ventricles

4

What brain structures are typically smaller in those with schizophrenia?

Hippocampus
Superior temporal gyrus
DLPFC
Amygdala
Thalamus

5

What has neuropathologic investigation shown about schizophrenic brains?

- Decreased size and packing density of pyramidal neurons in the PFC
- Reduced GABAergic neurons in layer III of the DLPFC
- Decreased dendritic spines
- Overall size decreases of roughly 3%

6

It's thought that in those with schizophrenia, the mesolimbic system has too ____________ dopamine, while the mesocortical system has too ____________ dopamine.

much; little

7

Schizophrenia seems to be caused, genetically, by ______________.

many small alleles

8

Idiosyncratic associations present in speech or writing are called _______________.

formal thought disorders

9

The rate of smoking in those with schizophrenia is ________ times that of the general population.

3

10

In addition to dopamine, what other neurotransmitter abnormality has been hypothesized to be associated with schizophrenia?

Hypoactivity of glutamate

11

True or false: there is tolerance to the antipsychotic effects of first-generation antipsychotics.

False.

12

Describe the GABAergic theory of schizophrenia.

Those with schizophrenia often have decreased levels of inhibitory interneurons in layer III of the prefrontal cortex, suggesting possible involvement of that area.

Decks in MS2 - Nervous System Class (111):