Flashcards in Psychotic Disorders Deck (12):
What is the monozygotic twin concordance rate for schizophrenia?
60% - 80%
At what age does schizophrenia usually present?
18 - 25 (earlier in men)
What did the first neuroanatomical comparison between schizophrenic and non-schizophrenic brains show?
That those with schizophrenia have larger lateral ventricles
What brain structures are typically smaller in those with schizophrenia?
Superior temporal gyrus
What has neuropathologic investigation shown about schizophrenic brains?
- Decreased size and packing density of pyramidal neurons in the PFC
- Reduced GABAergic neurons in layer III of the DLPFC
- Decreased dendritic spines
- Overall size decreases of roughly 3%
It's thought that in those with schizophrenia, the mesolimbic system has too ____________ dopamine, while the mesocortical system has too ____________ dopamine.
Schizophrenia seems to be caused, genetically, by ______________.
many small alleles
Idiosyncratic associations present in speech or writing are called _______________.
formal thought disorders
The rate of smoking in those with schizophrenia is ________ times that of the general population.
In addition to dopamine, what other neurotransmitter abnormality has been hypothesized to be associated with schizophrenia?
Hypoactivity of glutamate
True or false: there is tolerance to the antipsychotic effects of first-generation antipsychotics.