Flashcards in Pulmonary blood flow, VQ Deck (7)
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1
Q
What regulates pulmonary blood flow
A
Resistance of arterioles mediated by local vasoactive substances
2
Q
major factor that regulates pulmonary blood flow
A
PA.O2- alveolar
3
Q
Hypoxic vasoconstriction
A
Adaptation that reduces blood flow to poorly ventilated regions of the lung-good, decreases PAO2
4
Q
When is hypoxic vasoconstriction not a good adaptation
A
in severe lung disease (multi-lobar pneumonia) reduced blood flow to poorly ventilated areas causes hypoxemia
5
Q
What is the role of NO
A
potent vasodilator
6
Q
which vasoactive substances does the cycooxygenase pathway produce
A
- Thromboxane (vasoconstriction)
* Prostacyclin (vasodilation)
7
Q
What vasoactive substance does lipoxygenase pathway produce
A
Leukotrienes (vasoconstriction of blood vessels and airways)