Pump And Ion Exchangers Flashcards Preview

Sem 1: Pharamacology and Physiology > Pump And Ion Exchangers > Flashcards

Flashcards in Pump And Ion Exchangers Deck (21):
1

What is the function of the Na-K ATPase (Na pump)

(2)

- To form Na and K gradients
- drive secondary active transport

2

How many MTV does the Na-K ATPase pump contribute to the resting membrane potential?

5mV

3

What is the role of PMCA? (Plasma membrane calcium ATPase)

Expels residual calcium out of the cell

4

What is the affinity of PMCA like?

Low

5

What is the capacity of PMCA like?

High

6

What is the function of SERCA?

Removal of residual calcium into the SR

7

What is the affinity of SECRA like?

Low

8

What is the capacity of SERCA like?

High

9

What is the function of mitochondrial Ca uniports?

Operate at high calcium concentrations to buffer potentially damaging calcium

10

What is the function of NCX?

Expels intracellular calcium during cell recovery

11

Name the two channels involved in active transport.

PMCA
SERCA

12

Name a channel which uses secondary transport to function

NCX

13

Name a channel which uses facilitated transport to move ions.

Motchindrial ca uniports

14

What does the NCX exchange?

3 Na in for 1 ca out

15

What happens to the NCX during ischemia?

1. ATP depleted therefore the Na pump is depleted
2. Na accumulates depolarising cell
3. NCX reverses
4. Toxic calcium pumped into cell

16

Name 2 acid extruders.

NHE
NBC (sodium bicarbonate cotransporter)

17

Name 1 base extruder

AE

18

What does the NHE exchange?

One extracellular Na for one intracellular H

19

What receptor and location do loop directions act on?

NKCC2
Thick ascending limb

20

What receptor and location do Thiazides act on?

nCCT
DCT

21

What receptor and location do aldosterone antagonists act on.

ENaC
cortical collecting duct