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Flashcards in Q3 Deck (15):
1

T/F: Tetrodotoxin is derived from the puffer fish an is highly specific to Na channels.

True

2

4-Aminopyridine (4-AP) is a highly specific blocker of what ion channels?

K

3

T/F: Ionic pumps maintain the intracellular Na concentration at a high value and K concentration at a low value.

False

4

Mechanical trauma can damage nerve membranes and their proteins, making them more what to ions?

Leaky

5

What clamp (current or voltage) makes it possible to study currents through single ion channels?

Voltage

6

T/F: Conductances are calculated, not measured.

True

7

At any level of depolarization, which ionic current precedes K current?

Na

8

About 40% of which HH channels are inactivated at teh normal resting potetnial of -65mV?

Na

9

Does hyperpolarization remove inactivation with time?

Yes

10

Cooling a preparation has what effect on ion channel conductance kinetics?

Reduces the conductance and current.

11

Warming a preparation has what effect on ion channel conductance kinetics?

Increases the conductance and current.

12

What controls many processes fundamental to a living organism?

Ion channels

13

Neher and Sakmann invented which technique in 1976?

Voltage clamping

14

To observe single Na and K channels, what type of patch is used?

Outside-out patch

15

T/F: Channel openings are probabilistic.

True