Flashcards in Quiz 2 Deck (57):
the portion between the Fab and Fc region, which allows the two antigen-binding sites to bind to antigens separately
antibodies that contain different heavy chains belong to different isotypes. i.e. IgA and IgM are isotypes.
heavy-chain class (isotype) switching
parts of antigens that can be recognized by antibodies: linear epitopes and conformational epitopes.
~determined by Kd
increase in antigen binding strength
one antibody bind to two antigens (one is its original target and the other is a structure similar one)
CD3 and zeta
enzyme that mediates the V (D) J recombination (either H chain or L chain gene recombination)
RAG-1 and RAG-2
recombinase-activating gene 1 and 2
removes nucleotides from V, D, J gene segments at the sites of recombination.
Terminal deoxyribonucleotidyl transferase
the site of V-J or V-D-J recombination
precursor of B cells. haven't mature yet
have the ability to nake
surrogate light chain
expressed with miu protein on the pre-B cell
miu chain, surrogate light chain, Ig alpha and Ig beta signaling molecule
pre-BCR complex shut off the H chain gene recombination on the second chromosome
if kappa fails to recombinate, then lambda goes for it.
immature B cell
Ig M expressing B lymphocytes
mature B cell
IgD+ IgM+ cell
follicular B cell
most mature B cell
marginal-zone B cell
found at the margins of splenic follicles
a distinct population found in lymphoid organs and peritoneal cavity. Developed from different precursors from above two.
double negative T cells/ pro-T
do not express CD4 nor CD8
the invariant protein that beta chain protein associates with in Pro-T cell
immature T cell
double positive T cell. express both CD4 and CD8
major histocompatibility complex
different clones of CD4+ or CD8+ T cells can see peptides only when these peptides are displayed by that individual's MHC molecule
classical dendritic cells
located in tissues and lymphoid organs
dendritic in the skin
dendritic in the blood and tissue, major source of Type I interferon
a type of chemokine receptor
~produce chemokine that binds to CCR7
in the T cell zone of lymph nodes, produce chemokines that bind to CCR7
human leukocyte antigen
peptide binding cleft
peptide binding site on MHC I & II
polymorphic region for MHC Class I , for class II?
I: alpha 1 and alpha 2; II: alpha 1 and beta 1
nonpolymorphic region for MHC class I, class II ?
I: alpha 3- CD8 only; II: alpha2 and beta 2, CD4 only.
the set of MHC alleles present on each chromosome.