Quiz 2 Flashcards Preview

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Flashcards in Quiz 2 Deck (57):
1

CDR

complimentarity-determining region

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V region

variable region

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C region

constant region

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H

heavy chain

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L

light chain

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Fab

fragment, antigen-binding

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Fc

fragment, crystalline

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hinge region

the portion between the Fab and Fc region, which allows the two antigen-binding sites to bind to antigens separately

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isotype

antibodies that contain different heavy chains belong to different isotypes. i.e. IgA and IgM are isotypes.

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heavy-chain class (isotype) switching

literally ...

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epitopes/ determinants

parts of antigens that can be recognized by antibodies: linear epitopes and conformational epitopes.

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affinity

~determined by Kd

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affinity maturation

increase in antigen binding strength

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avidity

~

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cross-reaction

one antibody bind to two antigens (one is its original target and the other is a structure similar one)

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myeloma cell

~

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hybridoma

~

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CD3 and zeta

~

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D gene

diversity

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J gene

joining gene

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VDJ recombinase

enzyme that mediates the V (D) J recombination (either H chain or L chain gene recombination)

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RAG-1 and RAG-2

recombinase-activating gene 1 and 2

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exonuclease

removes nucleotides from V, D, J gene segments at the sites of recombination.

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N region

p96

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P-nucleotides

p96

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TdT

Terminal deoxyribonucleotidyl transferase

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CDR3

the site of V-J or V-D-J recombination

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Pro-B cell

precursor of B cells. haven't mature yet

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Pre-B cell

have the ability to nake

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surrogate light chain

expressed with miu protein on the pre-B cell

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Pre-BCR complex

miu chain, surrogate light chain, Ig alpha and Ig beta signaling molecule

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allelic exclusion

pre-BCR complex shut off the H chain gene recombination on the second chromosome

33

receptor editing

if kappa fails to recombinate, then lambda goes for it.

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immature B cell

Ig M expressing B lymphocytes

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mature B cell

IgD+ IgM+ cell

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follicular B cell

most mature B cell

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marginal-zone B cell

found at the margins of splenic follicles

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B-1 lymphocytes

a distinct population found in lymphoid organs and peritoneal cavity. Developed from different precursors from above two.

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double negative T cells/ pro-T

do not express CD4 nor CD8

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pre-T alpha

the invariant protein that beta chain protein associates with in Pro-T cell

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immature T cell

double positive T cell. express both CD4 and CD8

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MHC

major histocompatibility complex

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MHC restriction

different clones of CD4+ or CD8+ T cells can see peptides only when these peptides are displayed by that individual's MHC molecule

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APC

antigen-presenting cell

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classical dendritic cells

located in tissues and lymphoid organs

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langerhan cells

dendritic in the skin

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plasmacytoid cell

dendritic in the blood and tissue, major source of Type I interferon

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CCR7

a type of chemokine receptor

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lymphatic endothelium

~produce chemokine that binds to CCR7

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stromal cells

in the T cell zone of lymph nodes, produce chemokines that bind to CCR7

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HLA

human leukocyte antigen

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peptide binding cleft

peptide binding site on MHC I & II

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polymorphic region for MHC Class I , for class II?

I: alpha 1 and alpha 2; II: alpha 1 and beta 1

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nonpolymorphic region for MHC class I, class II ?

I: alpha 3- CD8 only; II: alpha2 and beta 2, CD4 only.

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MHC haplotype

the set of MHC alleles present on each chromosome.

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anchor residues

amino acid of the peptide antigen that anchors the peptides in the cleft