Quiz 8 Flashcards Preview

Pharmacology III > Quiz 8 > Flashcards

Flashcards in Quiz 8 Deck (20):
1

Drugs that may cause acute BPH

1. OTC cold meds
2. Allergy meds
3. Antihypertensives
4. Antiarrhythmics

Also - long periods of immobility

2

Classes of drugs to Tx BPH

1. Alpha-blockers
2. 5 alpha-reductase inhibitors
3. Phosphodiesterase-5 inhibitors

3

Alpha blockers for BPH

1. Flomax - Tamsulosin
2. Uroxatral - Alfuzosin

4

Which receptors does Flomax affect?

alpha 1A & 1D

Avoids alpha 1B affect so doesn't effect BP

For BPH

5

How do 5-alpha reductase inhibitors work?

Work only on prostate to dec. 5DHT

6

How long does it take to see effects from 5-alpha reductase inhibitors?

6-12 months

Resets PSA levels - get new baseline

7

ADRs 5-alpha reductase inhibitors

ex. Avodart - Dutasteride

1. Dec. libido
2. Ejaculatory disorder
3. Gynecomastia
4. Impotence

Maybe
1. Cardiac failure
2. Inc. TSH levels
3. Testicular swelling
4. Rash, urticaria

8

Types of drugs for erectile dysfunction

1. Androgens - testosterone
2. Phosphodiesterase inhibitors
3. Andrenergic-receptor antagonists

9

Contraindications to phoshodiesterase-5 inhibitors

1. Nitrate therapy

Caution w/ alpha-blockers

10

MOA phosphodiesterase-5 inhibitors

Increase cGMP so blood stays in penis

11

Which phosphodiesterase-5 inhibitor can be used every day?

Cialis - Tadalafil

Used for ED & BPH
May cause back pain/myalgias

12

What drugs might cause female sexual dysfunction?

SSRIs

13

Tx dyspareunia assoc. w/ vulvovaginal atrophy

Ospemifene - selective estrogen receptor modulator

14

Drugs to treat female sexual dysfunction

1. Estrogen - local
Not good:
2. Testosterone creams & gels
3. Sildenafil - Viagra

15

What is neoadjuvant therapy?

Administration of therapeutic agents before a main Tx
1. Reduce size or extent of CA
2. Determine response or resistance to a given agent
3. Try to make subsequent therapy easier & more likely to succeed

16

Name a selective estrogen receptor modulator

Tamoxifen - Novaldex

Prodrug - CYP2D6
Drug interaction - antidepressants

ADRs
1. Inc. risk of stroke
2. Flushing
3. Nausea
4. Fluid retention
5. Vaginal bleeding & d/c
6. Endometrial hyperplasia

17

How do aromatase inhibitors work?

CYP19A1
Prevent production of estrogen

18

Who should avoid aromatase inhibitors?

Women w/ intact ovaries - reactivation possible leading to inc. levels of estrogen

Good in postmenopausal women

19

ADRs Aromatase inhibitors

Ex. Anastrozole

Higher incidence than Tamoxifen
1. Osteoporosis
2. Fx
3. CV risk
4. Hypercholesterolemia
5. MSK issues

Lower risk of
1. Venous thrombosis
2. Endometrial CA

ADRs
1. Vasodilation
2. Fatigue
3. Hot flashes
4. GI distress
5. Mood disorder

20

What are the anti-her2 agents & ADRs?

Lapatinib - Tykerb

Oral - metabolized by CYP3A4
Eat on empty stomach - adequate hydration
Don't drink grapefruit juice! Can inc. drug levels

ADRs
1. GI
2. Acneform rash
3. Cardiac toxicity