Quiz 8 Reverse Flashcards Preview

Pharmacology III > Quiz 8 Reverse > Flashcards

Flashcards in Quiz 8 Reverse Deck (20):
1

1. OTC cold meds2. Allergy meds3. Antihypertensives4. Antiarrhythmics Also - long periods of immobility

Drugs that may cause acute BPH

2

1. Alpha-blockers2. 5 alpha-reductase inhibitors3. Phosphodiesterase-5 inhibitors

Classes of drugs to Tx BPH

3

1. Flomax - Tamsulosin2. Uroxatral - Alfuzosin

Alpha blockers for BPH

4

alpha 1A & 1D Avoids alpha 1B affect so doesn't effect BPFor BPH

Which receptors does Flomax affect?

5

Work only on prostate to dec. 5DHT

How do 5-alpha reductase inhibitors work?

6

6-12 monthsResets PSA levels - get new baseline

How long does it take to see effects from 5-alpha reductase inhibitors?

7

ex. Avodart - Dutasteride1. Dec. libido2. Ejaculatory disorder3. Gynecomastia4. ImpotenceMaybe1. Cardiac failure2. Inc. TSH levels3. Testicular swelling4. Rash, urticaria

ADRs 5-alpha reductase inhibitors

8

1. Androgens - testosterone2. Phosphodiesterase inhibitors3. Andrenergic-receptor antagonists

Types of drugs for erectile dysfunction

9

1. Nitrate therapyCaution w/ alpha-blockers

Contraindications to phoshodiesterase-5 inhibitors

10

Increase cGMP so blood stays in penis

MOA phosphodiesterase-5 inhibitors

11

Cialis - TadalafilUsed for ED & BPHMay cause back pain/myalgias

Which phosphodiesterase-5 inhibitor can be used every day?

12

SSRIs

What drugs might cause female sexual dysfunction?

13

Ospemifene - selective estrogen receptor modulator

Tx dyspareunia assoc. w/ vulvovaginal atrophy

14

1. Estrogen - localNot good:2. Testosterone creams & gels3. Sildenafil - Viagra

Drugs to treat female sexual dysfunction

15

Administration of therapeutic agents before a main Tx1. Reduce size or extent of CA2. Determine response or resistance to a given agent3. Try to make subsequent therapy easier & more likely to succeed

What is neoadjuvant therapy?

16

Tamoxifen - NovaldexProdrug - CYP2D6 Drug interaction - antidepressantsADRs1. Inc. risk of stroke2. Flushing3. Nausea4. Fluid retention5. Vaginal bleeding & d/c6. Endometrial hyperplasia

Name a selective estrogen receptor modulator

17

CYP19A1Prevent production of estrogen

How do aromatase inhibitors work?

18

Women w/ intact ovaries - reactivation possible leading to inc. levels of estrogen Good in postmenopausal women

Who should avoid aromatase inhibitors?

19

Ex. Anastrozole Higher incidence than Tamoxifen1. Osteoporosis2. Fx3. CV risk4. Hypercholesterolemia5. MSK issuesLower risk of 1. Venous thrombosis2. Endometrial CAADRs1. Vasodilation2. Fatigue3. Hot flashes4. GI distress5. Mood disorder

ADRs Aromatase inhibitors

20

Lapatinib - Tykerb Oral - metabolized by CYP3A4Eat on empty stomach - adequate hydrationDon't drink grapefruit juice! Can inc. drug levelsADRs1. GI2. Acneform rash3. Cardiac toxicity

What are the anti-her2 agents & ADRs?