Quiz 9 Reverse Flashcards Preview

Pharmacology III > Quiz 9 Reverse > Flashcards

Flashcards in Quiz 9 Reverse Deck (25):
1

1. Cross-linkage of DNA2. Breaks DNA3. Activator of cell cycle checkpoints resulting in apoptosis

How do alkylating agents work?

2

Bind to DNA1. Produce free radicals2. Damage DNA as single-strand breaks or cross-links

How do abx CA agents work?

3

inhibit kinetochores causing improper attachment to spindle microtubules Cells exit mitosis or dies

How do mitotic spindle inhibitors work?

4

Structurally similar to purine/pyrimidines1. Misincorporation into DNA2. Abnormal timing or progression through DNA synthesis3. Altered function of purine/pyrimidine biosynthetic enzymes

How do antimetabolites work?

5

Colony stimulating factors1. Filgrastin - Neupogem - G-CSF 2. Sargramostim - Leukine - GM-CSF

Stimulate WBC

6

1. 5-fluorouracil2. IrinotecanTx - Hydration, electrolytes, Loperamide, Octreotide if resistant

What onco drugs can cause severe diarrhea?

7

1. Anthracyclines2. Alkylating inhibitors3. Topoisomerase inhibitors

Which onco drugs cause ~100% hair loss?

8

1. Elimination of testosterone production2. LHRH w/ antiandrogen

Tx advanced prostate CA

9

Hypothalamus sit on receptors inc. T but then it shuts downCauses same T levels as surgical castration Sx get worse, then good!

Where do LHRH agonists work?

10

1. Goserelin - Zoladex2. Histrelin - Vantas3. Leuprolide - Lupron4. Triptorelin - Telstar

What are the LHRH agonists?

11

1. Abiraterone - Zytiga2. Bicalutamide - Casodex3. Enzalutamide - Xtandi4. Flutamide5. Nilutamide - Nilandron**Used in combination therapyCYP3A4 & 2C19

What are the antiandrogens?

12

Laser surgery

Tx closed angle glaucoma

13

1. Prostaglandin analogs2. Beta-blockers3. Miotics4. Carbonic anhydrase inhibitors5. Adrenergics

Tx open angle glaucoma

14

1st line Tx for open angle glaucoma1. Travoprost - Travatan Z2. Bimatoprost - Lumigan3. Latanoprost - XalatanCauses eyelashes to grow

Prostaglandin analogs

15

Timolo - Timoptic Avoid in asthma, COPD, advanced cardiac disease

Beta lockers for open angle glaucoma

16

Open angle glaucoma1. Carbachol2. Pilocarpine Causes visual changes - dec. vision at night

Miotics

17

Open angle glaucoma1. Dorzolamide - Trusopt2. Brizolamide - Azopt3. Acetazolamide - Diamox (PO)Weird taste, superficial punctate keratitis

Carbonic anhydrase inhibitors

18

Brimonidine - Alphagan PMacular edema, redness, irritation

Andrenergics for open angle glaucoma

19

1. Antihistamines2. Anticholinergics - oxybutynin, tolterodine, benztropine, trihexylphenidine, TCAs3. Chronic steroids4. Topiramate

What drugs might inc. IOP?

20

1. Naphazoline & PheniramineUse for 72h due to rebound vasodilation2. Ketotifen

Antihistamines for allergic conjunctivitis

21

1. Erythromycin (ointment)2. Polymyxin-trimethoprim (drops)

Tx bacterial conjunctivitis

22

Prevent progression of Dry AMD1. Vit C2. Vit E3. Zinc oxide4. Copper oxide5. Beta-carotene or Lutein/Zeaxanthin

AREDS formulation

23

VEGF - Vascular endothelial growth factor inhibitors1. Pegaptanib - Macugen2. Bevacizumab - Avastin3. Afilbercept - Elyea4. Ranibizumab - Lucentis ADRs1. Retinal detachment2. Hypersensitivity3. Inc. IOP4. Thromboembolic events5. Visual disturbances

Tx Wet AMD

24

Cyclosporin - Restasis Immunomodulator

No tears due to ocular inflammation?

25

1. Cilostazol - Pletal2. Clopidogrel/Aspirin3. Pentoxyfylline - Trental

Tx claudication