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Flashcards in quiz blood stuff Deck (32):
1

process of stopping blood loss

Hemostasis

2

principle mechanism of hemostasis

Blood coagulation

3

mesh of protein filaments that traps blood’s formed elements toform a red, gelatinous mass

Blood clot

4

Fibrin thread

threads that holds the blood cells together and they seal thewound to prevent loosing of blood

5

______ become activated upon injury through the extrinsic and intrinsic pathways

Clotting factors

6

____ present in the blood at all times in their inactive form and produced in the liver

Clotting factors

7

Vitamin K is required to produce _____( gut flora=Vit k, or from outside)

Clotting factors

8

CF I

Fibrinogen

9

CF II

Prothrombin

10

CF V

Preaccelerin

11

CF VII

Proconvertin

12

CF VIII

Antihemophilic factor

13

Christmas factor

CF IX

14

CF X

Stuart-Prower factor

15

CF XI

Plasma thromboplastin antecedent

16

CF XII

Hageman factor

17

CF XIII

Fibrin-stabilizing factor CF XIII

18

Damage to cells within blood vessels and outside of the vessels Tissue factor (aka Tissue Thromboplastin) – released by injured cells, bothinjured blood vessel cells and injured tissue cells, activates clotting factors Tissue factor  Proconvertin (CF 7)  Stuart-Prower factor (CF 10)

Extrinsic Pathway

19

Exposure of collagen fibers of subendothelial cells of blood vessels to blood flowactivates clotting factors This pathway ONLY occurs inside injured blood vessels2 Collagen fibers exposed  Hageman factor (CF 12)  Plasma thromboplastinantecedent (CF 11)  Christmas factor (CF 9)  Stuart-Prower factor (CF 10)

Intrinsic Pathway

20

 Picking up where the extrinsic and intrinsic pathways left off: activation of CF 10 CF 10  Prothromin (CF 2)  thrombin  fibrinogen (CF 1)  fibrin Fibrin forms a net and traps the formed elements in blood  COAGULATION(blood clot)

clotting cascade

21

___ is a necessary component of coagulation

Ca2+

22

Patients with severe blood loss are given _____ ____ injections to help withblood clotting

calcium chloride

23

 ONLY occurs inside injured blood vessels

Platelet Activation and the Platelet Plug

24

Platelet Activation and platelet plug release

1. exposure of collagen fibers of subendothelial cells of blood vessels toblood flow2. von Willebrand factor (circulating in blood in inactive form) becomesactivated and attaches to the exposed collagen fibers, stoppingmovement of platelets  platelets form a single layer on top of theexposed collagen3. Platelets become activated and then attach a second layer of platelets,etc. Platelet activation results in the formation of a platelet plug The platelet plug physically (mechanically) blocks the damaged blood vessel

25

can be formed inside and outside vessels

blood clots

26

can only be formed inside a blood vessel

platelet plugs

27

Activated platelets release

ADP – promotes platelet activationo Thromboxane A2 (TxA2) – vasoconstrictiono Growth factors – promote wound healing, fibroblast chemotaxis

28

3 components of Anticoagulation system

hemodynamicsendothelial mediationfibrinolitic sytem

29

Hemodynamics

– slow blood flow is important for coagulation otherwiseactivated CFs get washed out and a clot cannot be formed

30

Endothelial mediation

platelet plug is formed, surrounding uninjuredendothelial cells release prostacyclin (PGI2) which prevents extra orexcess platelet aggregation

31

Fibrinolitic system

– CF 12 also activates tissue plasminogen activator,which converts plasminogen into plasmin, resulting in degradation ofactivated CFs

32

–pinpoint hemorrhages (eg scury)

Petechiae