Flashcards in RA Pharm - Fitz Deck (11)
4 drugs classes (besides anti-inflammatories) for RA
Non-specific drug types for RA
- JAK inhibitor
4 DMARD (disease-modifying anti-rheumatic drugs)
MoA of Leflunamide
Inhibits dihydroorotate dehydrogenase
Frontline DMARD of choice for RA
**How does it work (for RA)?
Slowly becomes polyglutaminated within cells over 25-30 weeks (takes long time to reach steady state), then inhibits AICAR TRANSFORMYLASE. AICAR accumulation leads to ADENOSINE accumulation, which leads to ANTI-INFLAMMATORY effect
Methotrexate - major side effect
Should do what else with it?
Take folic acid or eat foods high in it
MoA of glucocorticoids in RA
Repress NFkB transcription factor, thus repressing transcription of cytokines secondarily
Etanercept - MoA
TNF receptor decoy, thus absorbing TNF-alpha
Anti-TNF monoclonal antibodies
IL-1 receptor antagonist
Anti-TNF agents (3)
All share what?
Etanercept, Infliximab, Adalimumab
Risk of serious opportunistic infections (TB, others)