Radiation Protection Flashcards
(42 cards)
What is Absorbed Dose and what are it’s units?
Measure of the amount of energy deposited in a medium per unit mass of the medium.
Units = Gray (Gy)
What is absorbed dose measured in?
Measure in Joules/kg
What is the subunit of absorbed dose?
milligrays (mGy) (x10^-3)
What is the equivalent dose?
Takes into account the different radio-biological effectiveness of different types of radiation.
How is equivalent dose calculated?
Equivalent dose = absorbed dose x radiation weighting factor
What is the weighting factor?
Weighting factor = Wr
X-rays, gamma rays and beta particles Wr = 1
Alpha particles Wr = 20
What is the unit of equivalent dose?
Sievert (Sv)
Sub-unit = millisieverts (mSv) (x10^-3)
microsieverts (x10^-6)
What is the equivalent dose, measured in Sieverts, equal to?
It is equal to the absorbed dose, measured in Grays, as the radiation weighting factor = 1.
What is the effective dose?
The effective dose allows doses from different investigations of different parts of the body to be compared.
It converts the dose to the equivalent whole body dose, as some body parts are more sensitive to radiation than others.
Use a tissue weighting factor (Wt)
How is effective dose calculated and what is it measured in?
Effective dose (E) = equivalent dose x tissue weighting factor Unit = Sievert Sub-unit = millisievert
What does the term dose usually mean?
Effective dose
What is the UK’s background radiation?
Average 2.5mSv per year
What are the two types of biological affects of radiation?
Somatic = affecting those irradiated, either deterministic or non-deterministic (stochastic) Genetic = affecting offspring of those irradiated, non-deterministic (stochastic)
What is meant by Deterministic affects of radiation?
The effects will occur, there is a threshold dose at which the effect begins to occur. Above the threshold, the severity of the effect increases with dose.
What are some deterministic effects?
Cataracts, gastrointestinal upset, suppression of erythropoiesis .
Do deterministic effects of radiation occur in dentistry?
No, they shouldn’t
What are the effects of radiation on the unborn child?
Related to dose so deterministic
Susceptible when the organs are developing (2-9 weeks)
Results in malformations (reduced growth) or death
Name 6 non-deterministic effects (Stochastic) of radiation?
It may occur, development is random
No threshold at which stochastic events begin to occur
Any dose of radiation may cause stochastic effects
Probability of event occurring increases with dose
Severity of event not effected by dose, all or nothing
Leukaemia’s and solid tumours
Do non-deterministic (stochastic) effects of radiation occur in dentistry?
Yes
Which cells are the most radiosensitive?
Those with high mitotic rate
those that are going to undergo many future mitoses
Those most primitive in differentiation
Lymphocytes and oocytes which are highly differentiated and non-dividing.
Effects of radiation can be direct or indirect, explain each.
Direct - Interacts with biological macromolecules (DNA, RNA, proteins and enzymes) causing ionisation and damage
Indirect - water is abundant in the body - most common damage.
Hydrogen and hydroxyl fee radicals produced by action of radiation on water
Free radicals can form toxic substances such as hydrogen peroxide.
What happens when DNA is changed/damaged?
DNA is the primary mechanism for cell death, mutation and carcinogenesis
Strands break, loss/change of base, disrupt bonds between strands
Can DNA be repaired?
Yes, but if both strands are broken close to each other, there can be misrepair as the intact strand is usually used as a template.
What is the risk of cancer in Scotland?
Currently the risk of getting cancer in their lifetime in Scotland is 1 in 3.