Rapid - Psychiatry Flashcards Preview

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Flashcards in Rapid - Psychiatry Deck (107):
1

Haloperidol

  • Potent Typical antipsychotic
    • Blocks D2 receptors → increases cAMP
  • Use:
    • Schizophrenia positive symp
    • Sedation
  • S/E:
    • extrapyramidal
    • neurologic (PD)
    • endocrine
    • QT prolongation

2

Fluphenazine

  • Potent typical antipsychotic
    • Blocks D2 receptors → increases cAMP
  • Use: Schizophrenia positive symp
  • S/E:
    • extrapyramidal
    • neurologic (PD)
    • endocrine
    • QT prolongation

3

Thioridazine

  • Low-potency typical antipsychotic
    • Blocks D2 receptors → increases cAMP
  • Use: Schizophrenia positive symp
  • S/E: 
    • iris pigmentation / retinal deposits
    • anticholinergic
    • antihistamine
    • a1 blockade
    • QT prolongation
    • arrhythmia

4

Chlorpromazine

  • Low-potency typical antipsychotic
    • Blocks D2 receptors → increases cAMP
  • Use: Schizophrenia positive symp
  • S/E: 
    • Corneal deposits
    • anticholinergic
    • antihistamine
    • a1 blockade → reduce BP
    • QT prolongation

5

Olanzapine

  • Atypical antipsychotic
    • Blocks D2 and 5-HT2 receptors
  • Use: Schizophrenia positive and negative symp
  • S/E:
    • Weight gain (Olanzapine → Obese)
    • QT prolongation

6

Clozapine

  • Atypical antipsychotic
    • Blocks D2 and 5-HT2 receptors
  • Use: Rx-resistant Schizophrenia positive and negative symp
  • S/E:
    • Agranulocytosis (watch BM clozely)
    • Myocarditis
    • Seizures
    • Weight gain
    • QT prolongation

7

Quetiapine

  • Atypical antipsychotic
    • Blocks D2 and 5-HT2 receptors
  • Use: Schizophrenia positive and negative symp
  • S/E: 
    • Cataracts
    • Abuse potential
    • QT prolongation

8

Risperidone

  • Atypical antipsychotic
    • Blocks D2 and 5-HT2 receptors
  • Use: Schizophrenia positive and negative symp
  • S/E:
    • HypERprolactinemia (→ galactorrhea, irreg menses)
    • QT prolongation

9

Aripiprazole

  • Atypical antipsychotic
    • Blocks D2 and 5-HT2 receptors
  • Use: Schizophrenia positive and negative symp
  • S/E:
    • Akathisia (agitation/distress)
    • QT prolongation
    • LOW incidence sedation / weight gain / diabetes

10

Ziprasidone

  • Atypical antipsychotic
    • Blocks D2 and 5-HT2 receptors
  • Use: Schizophrenia positive and negative symp
  • S/E: QT prolongation

11

Fluoxetine

  • SSRI
    • 4-8 weeks to take effect
  • Use:
    • depression
    • anxiety d/o
    • OCD
    • panic d/o
  • S/E:
    • SIADH
    • sexual dysfcn
    • serotonin synd

12

Paroxetine

  • SSRI
    • 4-8 weeks to take effect
  • Use:
    • Social Phobia
    • Erectile Dysfunction
    • depression
    • anxiety d/o
    • OCD
    • panic d/o
  • S/E:
    • SIADH
    • sexual dysfcn
    • serotonin synd

13

Sertraline

  • SSRI
    • 4-8 weeks to take effect
  • Use:
    • PTSD
    • depression
    • anxiety d/o
    • OCD
    • panic d/o
  • S/E:
    • SIADH
    • sexual dysfcn
    • serotonin synd

14

Citalopram

  • SSRI
    • 4-8 weeks to take effect
  • Use:
    • depression
    • anxiety d/o
    • OCD
    • panic d/o
  • S/E:
    • SIADH
    • sexual dysfcn
    • serotonin synd

15

venlafaxine

  • SNRI
  • Use:
    • depression
    • anxiety d/o
    • panic d/o
    • PTSD
  • S/E:
    • HTN
    • stimulant fx
    • sedation

16

Duloxetine

  • SNRI
  • Use:
    • depression
    • anxiety d/o
    • panic d/o
    • PTSD
  • S/E:
    • HTN
    • stimulant fx
    • sedation

17

Amitriptyline

  • TCA
    • Blocks NE and 5-HT reuptake
  • Use:
    • Peripheral neuropathy
    • Chronic pain
    • Major depression
    • Migraine prophylaxis
  • S/E:
    • Convulsions
    • Coma
    • Cardiotoxicity / QT prolongation
    • Anticholinergic

18

Nortriptyline

  • TCA
    • Blocks NE and 5-HT reuptake
  • Use:
    • Major depression
    • Peripheral neuropathy
    • Migraine prophylaxis
  • S/E: Fewest anticholinergic, BP effects
    • Convulsions
    • Coma
    • Cardiotoxicity / QT prolongation
    • Anticholinergic

19

Imipramine

  • TCA
    • Blocks NE and 5-HT reuptake
  • Use:
    • 2nd line for bed-wetting
    • Major depression
    • Peripheral neuropathy
    • Migraine prophylaxis
  • S/E:
    • Convulsions
    • Coma
    • Cardiotoxicity / QT prolongation
    • Anticholinergic

20

Desipramine

  • TCA
    • Blocks NE and 5-HT reuptake
  • Use:
    • Major depression
    • Peripheral neuropathy
    • Migraine prophylaxis
  • S/E: fewest of all TCAs
    • Convulsions
    • Coma
    • Cardiotoxicity / QT prolongation
    • Anticholinergic

21

Clomipramine

  • TCA
    • Blocks NE and 5-HT reuptake
  • Use:
    • 2nd line for OCD
    • Major depression
    • Peripheral neuropathy
    • Migraine prophylaxis
  • S/E:
    • Convulsions
    • Coma
    • Cardiotoxicity / QT prolongation
    • Anticholinergic

22

Doxepin

  • TCA
  • Blocks NE and 5HT reuptake
  • Use:
    • major depression
    • insomnia
    • OCD
    • peripheral neuropathy
    • migraine prophylaxis
  • S/E:
    • convulsions
    • coma
    • cardiotoxicity / QT prolongation
    • anticholinergic

23

Amoxapine

  • TCA
  • Blocks NE and 5HT reuptake
  • Use:
    • major depression
    • OCD
    • peripheral neuropathy
    • migraine prophylaxis
  • S/E:
    • convulsions
    • coma
    • cardiotoxicity / QT prolongation
    • anticholinergic

24

Tranylcypromine

  • MAOI
    • Decreases breakdown of DA / NE / 5-HT
  • Use:
    • Atypical depression
    • Anxiety d/o
  • S/E:
    • HTN crisis w/tyramine (wine, cheese, nuts)
    • CNS stim
    • Serotonin synd w/other meds that inc 5-HT
  • Wait 2wks after stopping MAOI to start serotonergic drugs to allow MAO regeneration

25

Phenelzine

  • MAOI
    • Decreases breakdown of DA / NE / 5-HT
  • Use:
    • Atypical depression
    • Anxiety d/o
  • S/E:
    • HTN crisis w/tyramine (wine, cheese, nuts)
    • CNS stim
    • Serotonin synd w/other meds that inc 5-HT
  • Wait 2wks after stopping MAOI to start serotonergic drugs to allow MAO regeneration

26

Isocarboxazid

  • MAOI
    • Decreases breakdown of DA / NE / 5-HT
  • Use:
    • Atypical depression
    • Anxiety d/o
  • S/E:
    • HTN crisis w/tyramine (wine, cheese, nuts)
    • CNS stim
    • Serotonin synd w/other meds that inc 5-HT
  • Wait 2wks after stopping MAOI to start serotonergic drugs to allow MAO regeneration

27

Selegiline

  • MAO-B inhibitor
    • Decreases breakdown of DA / NE / 5-HT
  • Use:
    • Slow progression of Parkinson's symptoms
  • S/E:
    • HTN crisis w/tyramine (wine, cheese, nuts)
    • CNS stim
    • Serotonin synd w/other meds that inc 5-HT
  • Wait 2wks after stopping MAOI to start serotonergic drugs to allow MAO regeneration

28

Lithium

  • Blocks dephosphorylation of IP3/DAG
  • Use: Bipolar d/o
  • S/E:
    • Movement d/o (tremor)
    • Nephrogenic DI
    • HypOthyroidism
    • Pregnancy prob
      • Ebstein anomaly → R atrium bigger, L heart smaller, BP lower
  • Toxicity w/Thiazides

29

Buspirone

  • Partial agonist at 5-HT1A receptors
    • Slow onset
  • Use: Generalized anxiety d/o
  • S/E:
    • Serotonin Synd
    • Extrapyramidal symp
  • Does NOT cause:
    • interaxn w/EtOH
    • sedation / addiction / tolerance
    • sexual dyfcn 

30

Bupropion

  • Atypical antidepressant
    • Increases NE and DA
  • Use:
    • Atypical depression
    • Smoking cessation
  • S/E:
    • Seizures in eating d/o pts
    • Stimulant fx
  • NO sexual dysfcn (bupropion for proper sex)

31

Mirtazapine

  • Atypical antidepressant
    • α2 Blocker
    • Also blocks 5-HT2, 5-HT3 receptors
  • Use: Atypical depression
  • S/E:
    • Sedation
    • Increased appetite
    • Weight gain
    • Dry mouth

32

Trazodone

  • Atypical antidepressant
    • Blocks α1, 5-HT2, H1 receptors
    • Also weakly inhibits 5-HT reuptake
  • Use:
    • Insomnia (inc REM sleep)
    • Atypical depression
  • S/E:
    • Priapism 
    • Sedation
      • (trazzzobone)
    • Postural hypOtension

33

Phenobarbital

  • Barbiturate
  • Binds GABAA receptor → increases duration of Cl- channel opening → hyperpolarization
  • Use:
    • Sedation
    • Anxiety
    • Simple Complex, Partial Complex, and Tonic-Clonic Seizures (1st line in neonates)
    • Insomnia
  • S/E:
    • Poss fatal resp and CV depression
    • CNS depression (worse w/EtOH)
    • Low therapeutic index
    • P450 inducer
  • C/I: Porphyria

34

Pentobarbital

  • Barbiturate
  • Binds GABAA receptor → increases duration of Cl- channel opening → hyperpolarization
  • Use:
    • Sedation
    • Anxiety
    • Seizures
    • Insomnia
  • S/E:
    • Poss fatal resp and CV depression
    • CNS depression (worse w/EtOH)
    • Low therapeutic index
    • P450 inducer
  • C/I: Porphyria

35

Thiopental

  • Barbiturate
  • Binds GABAA receptor → increases duration of Cl- channel opening → hyperpolarization
  • Use:
    • Induction of anesthesia
    • Sedation
    • Anxiety
    • Seizures
    • Insomnia
  • S/E:
    • Poss fatal resp and CV depression
    • CNS depression (worse w/EtOH)
    • Low therapeutic index
    • P450 inducer
  • C/I: Porphyria

36

Secobarbital

  • Barbiturate
  • Binds GABAA receptor → increases duration of Cl- channel opening → hyperpolarization
  • Use:
    • Sedation
    • Anxiety
    • Seizures
    • Insomnia
  • S/E:
    • Poss fatal resp and CV depression
    • CNS depression (worse w/EtOH)
    • Low therapeutic index
    • P450 inducer
  • C/I: Porphyria

37

Diazepam

  • Benzodiazepine
  • Binds GABAA receptor → increases frequency of Cl- channel opening → hyperpolarization
  • Use:
    • Anxiety
    • Spasticity
    • Status epilepticus
    • EtOH withdrawal, DTs
    • Night terrors
    • General anesthesia
    • Insomnia
  • S/E:
    • Dependence
    • CNS depression worse w/EtOH
  • OD: flumazenil

38

Lorazepam

  • Benzodiazepine
  • Binds GABAA receptor → increases frequency of Cl- channel opening → hyperpolarization
  • No active metabolite → better for elderly, liver failure
  • Use:
    • Anxiety
    • Spasticity
    • Status epilepticus
    • EtOH withdrawal, DTs
    • Night terrors
    • General anesthesia
    • Insomnia
  • S/E:
    • Dependence
    • CNS depression worse w/EtOH
  • OD: flumazenil

39

Oxazepam

  • Benzodiazepine
  • Binds GABAA receptor → increases frequency of Cl- channel opening → hyperpolarization
  • No active metabolite → better for elderly, liver failure
  • Use:
    • Anxiety
    • Spasticity
    • EtOH withdrawal, DTs
    • Night terrors
    • General anesthesia
    • Insomnia
  • S/E:
    • Dependence
    • CNS depression worse w/EtOH
  • OD: flumazenil

40

Benzos better for elderly / liver failure pts

No active metabolite (desmethyldiazepam)

LOT:

  • Lorazepam
  • Oxazepam
  • Temazepam

41

Short-acting benzos

Higher addictive potential

ATOM:

  • Alprazolam
  • Triazolam
  • Oxazepam
  • Midazolam

42

Temazepam

  • Benzodiazepine
  • Binds GABAA receptor → increases frequency of Cl- channel opening → hyperpolarization
  • No active metabolite → better for elderly, liver failure
  • Use:
    • Insomnia (maintain sleep)
    • Anxiety
    • Spasticity
    • EtOH withdrawal, DTs
    • Night terrors
    • General anesthesia
  • S/E:
    • Dependence
    • CNS depression worse w/EtOH
  • OD: flumazenil

43

Triazolam

  • Benzodiazepine
  • Binds GABAA receptor → increases frequency of Cl- channel opening → hyperpolarization
  • Use:
    • Insomnia (getting to sleep)
    • Anxiety
    • Spasticity
    • EtOH withdrawal, DTs
    • Night terrors
    • General anesthesia
  • S/E:
    • Dependence
    • CNS depression worse w/EtOH
  • OD: flumazenil

44

Midazolam

  • Benzodiazepine
  • Binds GABAA receptor → increases frequency of Cl- channel opening → hyperpolarization
  • Use:
    • Seizures
    • General anesthesia for short procedures
    • Anxiety
    • Spasticity
    • EtOH withdrawal, DTs
    • Night terrors
    • Insomnia
  • S/E:
    • Anterograde amnesia → date-rape drug
    • Dependence
    • CNS depression worse w/EtOH
  • OD: flumazenil

45

Chlordiazepoxide

  • Benzodiazepine
  • Binds GABAA receptor → increases frequency of Cl- channel opening → hyperpolarization
  • Use:
    • Anxiety
    • Spasticity
    • EtOH withdrawal, DTs
    • Night terrors
    • General anesthesia
    • Insomnia
  • S/E:
    • Dependence
    • CNS depression worse w/EtOH 
  • OD: flumazenil

46

Alprazolam

  • Benzodiazepine
  • Binds GABAA receptor → increases frequency of Cl- channel opening → hyperpolarization
  • Short-acting
  • Use:
    • Anxiety
    • Panic d/o
    • Specific phobias
    • Spasticity
    • EtOH withdrawal, DTs
    • Night terrors
    • General anesthesia
    • Insomnia
  • S/E:
    • Dependence
    • CNS depression worse w/EtOH
  • OD: flumazenil

47

Clonazepam

  • Benzodiazepine
  • Binds GABAA receptor → increases frequency of Cl- channel opening → hyperpolarization
  • Use:
    • Rx-resistant myoclonic / absence seizures
    • Anxiety
    • Spasticity
    • EtOH withdrawal, DTs
    • Night terrors
    • General anesthesia
    • Insomnia
  • S/E:
    • Dependence
    • Tolerance
    • CNS depression worse w/EtOH 
  • OD: flumazenil

48

Flunitrazepam

  • Benzodiazepine
  • Binds GABAA receptor → increases frequency of Cl- channel opening → hyperpolarization
  • Use: abused as date-rape drug

49

Benzo receptor agonist

  • Same action as benzos, but chemically different
  • Dec latency to fall asleep + inc sleep time
  • Less dependence
  • Less anxiolytic
  • Can still give flumazenil for OD

50

Eszopiclone

  • GABA BZ1 (benzo) receptor agonist
  • Decreases latency to fall asleep + increases sleep time
  • Use: Insomnia
  • S/E:
    • Sleepwalking
    • Ataxia
    • HA
    • Confusion
  • Less dependence, less anxiolytic
  • OD: flumazenil

51

Zolpidem

  • GABA BZ1 (benzo) receptor agonist
  • Decreases latency to fall asleep + increases sleep time
  • Use: Insomnia
  • S/E:
    • Sleepwalking
    • Ataxia
    • HA
    • Confusion
  • Less dependence, less anxiolytic
  • OD: flumazenil

52

Zaleplon

  • GABA BZ1 (benzo) receptor agonist
  • Decreases latency to fall asleep + increases sleep time
  • Use: Insomnia (short-term)
  • S/E:
    • Sleepwalking
    • Ataxia
    • HA
    • Confusion
  • Less dependence, less anxiolytic
  • OD: flumazenil
  •  

53

Ramelteon

  • Type 1 and 2 melatonin receptor agonist
  • Use: insomnia

54

Suvorexant

  • Orexin antagonist
  • Prevents stimulation / "wake" signals

55

Antihistamines for insomnia

  • Drugs:
    • Diphenhydramine
    • Doxylamine
    • Hydroxyzine
  • Use: Best for pts w/allergies and pruritis that disrupt sleep patterns
  • Tolerance develops w/i 4 days
  • S/E: anticholinergic

56

Carbamazepine

  • Anti-epileptic
  • Increases Na+ channel inactivation in cortical neurons
  • Undergoes autoinduction (t1/2 decreases) → slowly increase dose to keep therapeutic
  • Use:
    • Trigeminal neuralgia (1st line)
    • Simple and Complex Partial Seizures (1st line)
    • Tonic-Clonic Seizures (1st line)
  • S/E:
    • Blood dyscrasias
    • Liver toxicity
    • SIADH
    • SJS
    • Hyponatremia
    • Diplopia
    • Ataxia
    • Teratogenesis
  • P450 inducer

57

Valproic Acid

  • Anti-epileptic
    • Increases Na+ channel inactivation
    • Inhibits GABA transaminase → increases GABA concentration
  • Use:
    • Tonic-Clonic Seizures (1st line)
    • Simple and Complex Partial Seizures
    • Absence Seizures
    • Myoclonic Seizures
    • Bipolar D/O maintenance
  • S/E:
    • BM suppression
    • Teratogenesis: Neural tube defects
    • GI distress
    • Hepatotoxicity (can be fatal)
    • Tremor
    • Weight gain
    • Alopecia

58

Stevens-Johnson Syndrome (SJS)

  • Prodrome of malaise and fever followed by rapid onset of erythematous/purpuric macules (oral, ocular, genital)
  • Skin lesions progress to epidermal necrosis and sloughing

59

5 Typical Antipsychotic Drugs

  1. Haloperidol
  2. Fluphenazine
  3. Trifluoperazine
  4. Thioridazine
  5. Chlorpromazine

60

10 Atypical Antipsychotic Drugs

  1. Aripiprazole
  2. Asenapine
  3. Clozapine
  4. Olanzapine
  5. Quetiapine
  6. Risperidone
  7. Iloperidone
  8. Lurasidone
  9. Paliperadone
  10. Ziprasidone

61

4 SSRI Drugs

  • Fluoxetine
  • Paroxetine
  • Sertraline
  • Citalopram

62

6 SNRI Drugs

  1. Venlafaxine
  2. Desvenlafaxine
  3. Duloxetine
  4. Maprotiline
  5. Milnacipran
  6. Levomilnacipran

63

TCA Drugs

  • Amitriptyline
  • Nortriptyline
  • Imipramine
  • Desipramine
  • Clomipramine
  • Doxepin
  • Amoxapine

64

MAOI Drugs

  • Tranylcypromine
  • Phenelzine
  • Isocarboxazid
  • Selegiline

65

Atypical Antidepressant Drugs

  • Bupropion
  • Mirtazapine
  • Trazodone

66

Barbiturate Drugs

  • Phenobarbital
  • pentobarbital
  • thiopental
  • secobarbital

67

Benzodiazepine Drugs

  • Diazepam
  • lorazepam
  • triazolam
  • temazepam
  • oxazepam
  • midazolam
  • alprazolam
  • chlordiazepoxide

68

Non-Benzo Hypnotics

  • Zolpidem
  • Zaleplon
  • Zopiclone

69

Flumazenil

  • Competitive antagonist at GABA benzodiazepine receptor
  • Use: Reversal of benzo OD

70

Beta-blockers

1st line for short-term treatment of anxiety (stage fright)

71

Cyproheptadine

  • 1st-gen antihistamine w/anti-5HT properties
  • Use: Serotonin syndrome

72

Methylphenidate

  • Stimulant
  • Inhibits DAT and NET → decreases reuptake of DA and NE
  • Use: ADHD
  • S/E
    • Tic disorders (transient and chronic)
    • DA elevation – may worsen pre-existing psychosis
    • Abuse potential
  • Interactions
    • CYP 2D6 inhibitors (SSRIs)
    • MAOIs
    • TCAs
    • Phenytoin
    • Clonidine

73

Amphetamines

  • Stimulants
  • Inhibit DAT and NET → decrease reuptake of DA and NE and enhance DA release
  • Use: ADHD
  • S/E: CV events

74

Atomoxetine

  • NON-stimulant
  • Selective NE reuptake inhibitor
  • Use: ADHD
  • S/E:
    • Severe liver disease
    • Potential suicidal ideation

75

ADHD Rx Preference

  1. Stimulants
  2. Non-stimulants
  3. TCAs, Bupropion
  4. Clonidine, Guanfacine

76

Escitalopram

  • SSRI
  • Helps restore memory post-stroke

77

Maprotiline

  • SNRI
  • Use: Depression
  • S/E:
    • Orthostatic HypOtension
    • Sedation

78

Prochlorperazine

  • Potent typical antipsychotic
    • Blocks D2 receptors → increases cAMP
  • Use:
    • Schizophrenia positive symp
    • Anti-emetic in adults
  • S/E:
    • extrapyramidal
    • endocrine
    • neurologic (PD)
    • QT prolongation

79

Promethazine

  • Potent typical antipsychotic
    • Blocks D2 receptors → increases cAMP
  • Use:
    • Schizophrenia positive symp
    • Anti-emetic in kids
  • S/E:
    • extrapyramidal
    • endocrine
    • neurologic (PD)
    • QT prolongation

80

Trifluoperazine

  • Potent typical antipsychotic
    • Blocks D2 receptors → increases cAMP
  • Use: Schizophrenia positive symp
  • S/E:
    • extrapyramidal
    • endocrine
    • neurologic (PD)
    • QT prolongation

81

Rx for tyramine-induced crisis w/MAOI

Phentolamine

82

Akasthisia

Restlessness w/inability to sit still

(Extrapyramidal effect of antipsychotics)

83

Tardive Dyskinesia

Involuntary movements (lip smacking) after prolonged antipsychotic use

84

DRESS Syndrome

Drug Rxn w/Eosinophilia & Systemic Symptoms

  • 2-8wks after drug exposure
    • Anticonvulsants
    • Allopurinol
    • Sulfonamides
    • Antibiotics
  • Fever
  • Generalized LAD
  • Facial Edema
  • Morbiliform Skin Rash
  • Internal Organ Dysfcn

85

3 High-Potency Typical Antipsychotics

  1. Trifluoperazine
  2. Fluphenazine
  3. Haloperidol

Tri to Fly High

  • Neuro side effects (extrapyramidal)

86

2 Low-Potency Typical Antipsychotics

  1. Chlorpromazine
  2. Thioridazine

Cheating Thieves are Low

  • Non-neuro side effects (antihistamine, anticholinergic, alpha blocking)

87

Desvenlafaxine

  • SNRI
  • Use:
    • depression
    • anxiety d/o
    • panic d/o
    • PTSD
  • S/E:
    • HTN
    • stimulant fx
    • sedation

88

Levomilnacipran

  • SNRI
  • Use:
    • depression
    • anxiety d/o
    • panic d/o
    • PTSD
  • S/E:
    • HTN
    • stimulant fx
    • sedation

89

Milnacipran

  • SNRI
  • Use:
    • depression
    • anxiety d/o
    • panic d/o
    • PTSD
  • S/E:
    • HTN
    • stimulant fx
    • sedation

90

Asenapine

  • Atypical antipsychotic
    • Blocks D2 and 5-HT2 receptors
  • Use: Schizophrenia positive and negative symp
  • S/E:
    • QT prolongation
    • Metabolic syndrome

91

Iloperidone

  • Atypical antipsychotic
    • Blocks D2 and 5-HT2 receptors
  • Use: Schizophrenia positive and negative symp
  • S/E: QT prolongation

92

Paliperidone

  • Atypical antipsychotic
    • Blocks D2 and 5-HT2 receptors
  • Use: Schizophrenia positive and negative symp
  • S/E: QT prolongation

93

SSRI uses

  • Depression
  • Gen anxiety d/o
  • Social anxiety d/o
  • Panic d/o
  • OCD
  • Bulimia
  • PTSD
  • Premature ejaculation
  • PMDD

94

SNRI uses

  • Depression
  • Gen anxiety d/o
  • Diabetic neuropathy
  • Social anxiety d/o (Venlafaxine)
  • Panic d/o (Venlafaxine)
  • PTSD (Venlafaxine)
  • OCD (Venlafaxine)

95

Typical Antipsychotic uses

  • Schizophrenia positive symptoms
  • Psychosis
  • Bipolar d/o
  • Delirium
  • Tourette
  • Huntington's
  • OCD

96

Atypical Antipsychotic uses

  • Schizophrenia positive and negative symptoms
  • Bipolar d/o
  • OCD
  • Anxiety d/o
  • Depression
  • Mania
  • Tourette

97

CNS Stimulant uses

  • ADHD
  • Narcolepsy
  • Appetite control

98

TCA uses

  • Major depression
  • OCD (Clomipramine)
  • Peripheral neuropathy
  • Chronic pain
  • Migraine prophylaxis

99

Rx TCA-induced Arrhythmia

NaHCO3

100

5 Drugs C/I with MAOIs

  1. SSRIs
  2. TCAs
  3. St John's Wort
  4. Meperidine (Demerol)
  5. Dextromethorphan

101

Varenicline

  • Nicotinic Ach Receptor Partial Agonist
  • Use: Smoking cessation
  • S/E: Sleep disturbance

102

Antidepressant MOAs

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103

Guanfacine

  • α2 Agonist
  • Use:
    • ADHD
    • Tourette
    • HTN emergency

104

Clonidine

  • α2 Agonist
  • Use:
    • ADHD
    • Tourette
    • HTN emergency

105

Sodium Oxybate

  • GHB
  • Use: Nighttime Narcolepsy

106

Modafinil

  • CNS Stimulant
  • Use: Daytime Narcolepsy

107

Pimozide

  • Antipsychotic
  • Use: Tourette