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Flashcards in Rapid Review Deck (34):
1

Four causes of microcytic anemia

TICS

1) Thalassemia
2) Iron deficiency
3) Chronic disease
4) Sideroblastic anemia

2

An elderly man with hypochromic, microcytic anemia is asymptomatic. Diagnostic tests?

FOBT and sigmoidoscopy

Suspect CRC

3

Precipitants of hemolytic crisis in patients with G6PD deficiency

Sulfonamides, antimalarial drugs, fava beans

4

Most common inherited cause of hypercoagulability

Factor V Leiden mutation

5

Most common inherited bleeding disorder

von Willebrand's disease

6

Most common inherited hemolytic anemia

Hereditary spherocytosis

7

Diagnostic test for hereditary spherocytosis

Osmotic fragility test

8

Pure RBC aplasia

Diamond-Blackfan anemia

9

Anemia associated with absent radii and thumbs, diffuse hyperpigmentation, cafe-au-lait spots, microcephaly and pancytopenia

Fanconi's anemia

10

Meds and viruses that lead to aplastic anemia

1) Chloramphenicol

2) Sulfonamides

3) Radiation

4) HIV

5) Chemotherapy

6) Hepatitis

7) Parvo B19

8) EBV

11

How to distinguish polycythemia vera from secondary polycythemia

Both have increased Hct and RBC mass, but polycythemia vera should have normal O2 sat and low EPO levels

12

TTP pentad?

FAT RN

Fever
Anemia
Thrombocytopenia
Renal dysfunction
Neuro abnormalities

13

HUS triad?

Anemia, thrombocytopenia, and ARF

14

Treatment for TTP

Emergent large-volume plasmapheresis, corticosteroids, antiplatelet drugs. Platelet transfusion contraindicated

15

Treatment for ITP in children

Usually resolves spontaneously

May require IVIG and/or corticosteroids

16

Which of the following are increased in DIC: Fibrin split products, D-dimer, fibrinogen, platelets, Hct?

Fibrin split products and D-dimer are elevated

Platelets, fibrinogen, and Hct are low

17

An 8 year old boy presents with hamarthrosis and increased PTT with normal PT and bleeding time. Diagnosis? Treatment?

Hemophilia A or B

Consider desmopressin (for Hemophilia A) or factor VIII or IX supplements

18

14 year old girl presents with prolonged bleeding after dental surgery and with menses, normal PT, normal or increased PTT and increased bleeding time. Diagnosis? Tx?

vWD

Treat with desmopressin, FFP, or cryoprecipitate

19

60 year old African American man presents with bone pain. What might a workup for MM reveal?

Monoclonal gammopathy, Bence Jones proteinuria, and "punched out" lesions on XR of skull and long bones

20

Reed-sternberg cells

Hodgkin's lymphoma

21

10 year old boy presents with fever, weight loss, and night sweats. Exam shows anterior mediastinal mass. Suspected dx?

Non-hodgkin's lymphoma

22

Microcytic anemia with low serum iron, low TIBC and normal or high ferritin

Anemia of chronic disease

23

Microcytic anemia with low serum iron, low ferritin, and increased TIBC

Iron deficiency anemia

24

An 80 year old man presents with fatigue, LAD, splenomegaly, and isolated lymphocytosis. What is the suspected diagnosis?

CLL

25

Lymphoma equivalent of CLL

Small lymphocytic lymphoma

26

A late, life-threatening complication of CML

Blast crisis (fever, bone pain, splenomegaly, pancytopenia)

27

Auer rods on blood smear

AML

28

AML subtype associated with DIC. Tx?

M3. Retinoic acid.

29

Electrolyte changes in tumor lysis syndrome

1) Low Calcium
2) High K
3) High P
4) High uric acid

30

50 year old man presents with early satiety, splenomegaly, and bleeding. Cytogenetics show t(9,22). Diagnosis?

CML

31

Heinz bodies

Intracellular inclusions seen in thalassemia, G6PD deficiency, and postsplenectomy

32

Virus associated with aplastic anemia in patients with sickle cell anemia

Parvo B19

33

25 year old African American man with sickle cell anemia has sudden onset of bone pain. Management of pain crisis?

O2, analgesia, hydration, and if severe then transfusion

34

A significant cause of morbidity in thalassemia patients. Treatment?

Iron overload

Use deferoxamine