Flashcards in Rapid Review Deck (34):
Four causes of microcytic anemia
2) Iron deficiency
3) Chronic disease
4) Sideroblastic anemia
An elderly man with hypochromic, microcytic anemia is asymptomatic. Diagnostic tests?
FOBT and sigmoidoscopy
Precipitants of hemolytic crisis in patients with G6PD deficiency
Sulfonamides, antimalarial drugs, fava beans
Most common inherited cause of hypercoagulability
Factor V Leiden mutation
Most common inherited bleeding disorder
von Willebrand's disease
Most common inherited hemolytic anemia
Diagnostic test for hereditary spherocytosis
Osmotic fragility test
Pure RBC aplasia
Anemia associated with absent radii and thumbs, diffuse hyperpigmentation, cafe-au-lait spots, microcephaly and pancytopenia
Meds and viruses that lead to aplastic anemia
7) Parvo B19
How to distinguish polycythemia vera from secondary polycythemia
Both have increased Hct and RBC mass, but polycythemia vera should have normal O2 sat and low EPO levels
Anemia, thrombocytopenia, and ARF
Treatment for TTP
Emergent large-volume plasmapheresis, corticosteroids, antiplatelet drugs. Platelet transfusion contraindicated
Treatment for ITP in children
Usually resolves spontaneously
May require IVIG and/or corticosteroids
Which of the following are increased in DIC: Fibrin split products, D-dimer, fibrinogen, platelets, Hct?
Fibrin split products and D-dimer are elevated
Platelets, fibrinogen, and Hct are low
An 8 year old boy presents with hamarthrosis and increased PTT with normal PT and bleeding time. Diagnosis? Treatment?
Hemophilia A or B
Consider desmopressin (for Hemophilia A) or factor VIII or IX supplements
14 year old girl presents with prolonged bleeding after dental surgery and with menses, normal PT, normal or increased PTT and increased bleeding time. Diagnosis? Tx?
Treat with desmopressin, FFP, or cryoprecipitate
60 year old African American man presents with bone pain. What might a workup for MM reveal?
Monoclonal gammopathy, Bence Jones proteinuria, and "punched out" lesions on XR of skull and long bones
10 year old boy presents with fever, weight loss, and night sweats. Exam shows anterior mediastinal mass. Suspected dx?
Microcytic anemia with low serum iron, low TIBC and normal or high ferritin
Anemia of chronic disease
Microcytic anemia with low serum iron, low ferritin, and increased TIBC
Iron deficiency anemia
An 80 year old man presents with fatigue, LAD, splenomegaly, and isolated lymphocytosis. What is the suspected diagnosis?
Lymphoma equivalent of CLL
Small lymphocytic lymphoma
A late, life-threatening complication of CML
Blast crisis (fever, bone pain, splenomegaly, pancytopenia)
Auer rods on blood smear
AML subtype associated with DIC. Tx?
M3. Retinoic acid.
Electrolyte changes in tumor lysis syndrome
1) Low Calcium
2) High K
3) High P
4) High uric acid
50 year old man presents with early satiety, splenomegaly, and bleeding. Cytogenetics show t(9,22). Diagnosis?
Intracellular inclusions seen in thalassemia, G6PD deficiency, and postsplenectomy
Virus associated with aplastic anemia in patients with sickle cell anemia
25 year old African American man with sickle cell anemia has sudden onset of bone pain. Management of pain crisis?
O2, analgesia, hydration, and if severe then transfusion