Rate-Determining Enzymes of Metabolic Processes Flashcards Preview

Step 1 > Rate-Determining Enzymes of Metabolic Processes > Flashcards

Flashcards in Rate-Determining Enzymes of Metabolic Processes Deck (13):
1

Glycolysis

Enzyme: Phosphofructokinase-1 (PFK-1)
Regulators: AMP +, fructose-2,6-BP+, ATP -, citrate -

2

Gluconeogenesis

Enzyme: Fructose-1,6-bisphosphatase
Regulators: ATP +, AMP -, fructose-2,6-BP -

3

TCA cycle

Enzyme: Isocitrate dehydrogenase
Regulators: ADP +, ATP -, NADH -

4

Glycogen synthesis

Enzyme: Glycogen synthase
Regulators: Glucose +, insulin +, epinephrine -, glucagon -

5

Glycogenolysis

Enzyme: Glycogen phosphorylase
Regulators: AMP +, epinephrine +, glucagon +, insulin -, ATP -

6

HMP shunt

Enzyme: Glucose-6-phosphate dehydrogenase (G6PD)
Regulators: NADP+ +, NADPH -

7

De novo pyrimidine synthesis

Enzyme: Carbamoyl phosphate synthetase II
Regulators:

8

De novo purine synthesis

Enzyme: Glutamine-PRPP amidotransferase
Regulators: AMP -, IMP -, GMP -

9

Urea cycle

Enzyme: Carbamoyl phosphate synthetase I
Regulators: N-acetylglutamate +

10

Fatty acid synthesis

Enzyme: Acetyl-CoA carboxylase (ACC)
Regulators: Insulin +, citrate +, glucagon -, palmitoyl-CoA -

11

Fatty acid oxidation

Enzyme: Carnitine acyltransferase I
Regulators: Malonyl-CoA -

12

Ketogenesis

Enzyme: HMG-CoA synthase
Regulators:

13

Cholesterol synthesis

Enzyme: HMG-CoA reductase
Regulators: Insulin +, thyroxine +, glucagon -, cholesterol -

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