Rate-limiting enzymes of metabolic pathways Flashcards Preview

Step One R&M > Rate-limiting enzymes of metabolic pathways > Flashcards

Flashcards in Rate-limiting enzymes of metabolic pathways Deck (24):
1

+ ADP

- ATP, NADPH

TCA cycle

2

+ AMP, F-2,6-BP

- ATP, citrate

Glycolysis

2

- Malonyl-Coa

FA oxidation

3

+ ATP, acetyl-CoA

- F-2,6-BP, AMP

Gluconeogenesis

4

+ Insulin, citrate

- glucagon, palmitoyl-CoA

FA synthesis

5

Gluconeogenesis

Fructose-1,6-bisphosphatase

6

+ epinephrine, glucagon, AMP

- insulin, G6P, ATP

Glycogenolysis

6

+ Insulin, thyroxine

- Glucagon, cholesterol

Cholesterol synthesis

8

TCA cycle

Isocitrate dehydrogenase

8

HMP shunt

G6PD

9

+ N-acetylglutamate

Urea cycle

10

+ G6P, insulin, cortisol

- glucagon, epinephrine

Glycogenesis

11

+ NADP-

- NADPH

HMP shunt

12

Glycogenolysis

Glycogen phosphorylase

13

De novo pyrimidine synthesis

Carbamoyl phosphatae synthetase II

14

- AMP, IMP, GMP

De novo purine synthesis

16

Ketogenesis

HMG CoA synthase

17

De novo purine synthesis

Glutamine-PRPP-amidotransferase

18

Glycogenesis

Glycogen synthase

20

Urea cycle

Carbamoyl phosphate synthetase I

21

Cholesterol synthesis

HMG CoA reductase

22

Fatty acid oxidation

Carnitine acyltransferase I

23

Glycolysis

PFK-1

24

Fatty acid synthesis

Acetyl-CoA carboxylase