Rate-limiting enzymes of metabolic pathways Flashcards

1
Q

+ ADP

  • ATP, NADPH
A

TCA cycle

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2
Q

+ AMP, F-2,6-BP

  • ATP, citrate
A

Glycolysis

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2
Q
  • Malonyl-Coa
A

FA oxidation

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3
Q

+ ATP, acetyl-CoA

  • F-2,6-BP, AMP
A

Gluconeogenesis

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4
Q

+ Insulin, citrate

  • glucagon, palmitoyl-CoA
A

FA synthesis

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5
Q

Gluconeogenesis

A

Fructose-1,6-bisphosphatase

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6
Q

+ epinephrine, glucagon, AMP

  • insulin, G6P, ATP
A

Glycogenolysis

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6
Q

+ Insulin, thyroxine

  • Glucagon, cholesterol
A

Cholesterol synthesis

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8
Q

TCA cycle

A

Isocitrate dehydrogenase

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8
Q

HMP shunt

A

G6PD

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9
Q

+ N-acetylglutamate

A

Urea cycle

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10
Q

+ G6P, insulin, cortisol

  • glucagon, epinephrine
A

Glycogenesis

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11
Q

+ NADP-

  • NADPH
A

HMP shunt

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12
Q

Glycogenolysis

A

Glycogen phosphorylase

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13
Q

De novo pyrimidine synthesis

A

Carbamoyl phosphatae synthetase II

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14
Q
  • AMP, IMP, GMP
A

De novo purine synthesis

16
Q

Ketogenesis

A

HMG CoA synthase

17
Q

De novo purine synthesis

A

Glutamine-PRPP-amidotransferase

18
Q

Glycogenesis

A

Glycogen synthase

20
Q

Urea cycle

A

Carbamoyl phosphate synthetase I

21
Q

Cholesterol synthesis

A

HMG CoA reductase

22
Q

Fatty acid oxidation

A

Carnitine acyltransferase I

23
Q

Glycolysis

A

PFK-1

24
Q

Fatty acid synthesis

A

Acetyl-CoA carboxylase