Rate-Limiting Enzymes of metabolic processess Flashcards Preview

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Flashcards in Rate-Limiting Enzymes of metabolic processess Deck (13):
1

Glycolysis

PFK-1 (+ AMP, + Fructose-2,6 bisphosphate, - ATP, -Citrate

2

Gluconeogenesis

Fructose-1,6-bisphospatase (+ATP, +acetyl-coA, -AMP, -fructose-2,6bisphosphate)

3

TCA cycle

Isocitrate DH (+ADP, -ATP, -NADH)

4

Glycogenesis

Glycogen synthase (+glucose-6-phosphate, +insulin, +cortisol, -epinepherine, -glucagon)

5

Glycogenolysis

Glycogen phosphorylase (+epinepherine, +glucagon, +AMP, -glucose-6-phosphate, -insulin, -ATP)

6

HMP shunt

Glucose-6-phosphate DH (+ NADP, - NADPH)

7

De novo pyrimidine synthesis

Carbamoyl phosphate synthetase

8

De novo purine synthesis

Glutamine-phosphoribosylpyrophosphate (PRPP) amidotransferase (-AMP, - inosine monophosphate (IMP), -
GMP)

9

Urea Cycle

Caramoyl phosphate synthetase I (+ N-acetylglutamate)

10

Fatty acid synthesis

Acetyl-CoA carboxylase (+ insulin, + citrate, - glucagon, - palmitoyl-CoA)

11

Fatty acid oxidation

Carnitine acyltransferase I (- Malonyl-CoA)

12

Ketogenesis

HMG-CoA synthase

13

Choleterol synthesis

HMG-CoA reductase (+ insulin, + thyroxine, - glucagon, -cholesterol)