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Reglering - gentranskription.. Flashcards

(10 cards)

1
Q

Vad för slags faktorer leder till G0->G1?

A

TF - t.ex. PDGF

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2
Q

Vad har tidiga- och sena gener för samband?

A

Tidiga ger upphov till sena

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3
Q

Vilka är de tidiga generna?

A

Jun, Fos, Myc

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4
Q

Vad bildas när Fos och Jun dimeriseras?

A

AP1 = TF för de sena G-fas-generna

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5
Q

Vilka signalvägar kan aktivera de tidiga generna?

A

STAT (Cytokin), Ras-MAP, PLC…

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6
Q

Vad kan myc bilda en dimer med?

A

Myc-Max (TF för sena gener)

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7
Q

Vad har AP1 och Myc-Max för funktion?

A

transkription av sena G-fas-gener - förbereda cellen för S-fas

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8
Q

Vad händer under sena perioden =delayed response

A

Pre-replikationskomplex bildas

Ökad proteinsyntes

Syntes av organeller

Transkription, bla av G1-cyklin/Cdk

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9
Q

Är uppkomsten av G1-cyklin/cdk en efterföljd av delayed response?

A

Ja.

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10
Q

Early response och delayed response genes måste ha bildats för att kunna passera___

A

restriction point

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