regulation of glycolysis and gluconeogenesis Flashcards

1
Q

which out of hexokinase and glucokinase is product inhibited?

A

hexokinase (glucose 6-p)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

genetic deficiency of glucokinase

A

MODY 2- impaired insulin secretion from beta cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

where is inactive glucokinase located

A

in the nucleus at high fructose 6p levels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

km and vmax for glucokinase

A

high km and high vmax. low affinity for glucose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

citrate inhibits

A

PFK-1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

pyruvate kinase ATP inhibition is overcome by

A

fructose 1,6 bp

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

PFK-1 ATP inhibition is overcome by

A

fructose 2,6 bp

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

substrates needed for gluconeogenesis

A

lactate, alanine, glutamine, NAD+, glycerol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

besides ATP, how is pyruvate kinase inhibited

A

glucagon sends pkA over to phosphorylate pyruvate kinase to make it inactive. (allows usage of PEP for gluconeogenesis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly