Renal Control Of Body Fluid Volume And Osmolarity Flashcards Preview

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Flashcards in Renal Control Of Body Fluid Volume And Osmolarity Deck (22):
1

What kind of hormone is ADH

Neurohomone

2

Where is ADH produced

In the hypothalamus

3

How does ADH work roughly

Form hypothalamus
Down axons
Posterior pituitary

4

How is the need for ADH production detected

Osmoreceptors

5

What effect does the ADH have on the permeability of the distal tubule

ADH from the blood
Bind to type 2 vasopressin receptor at basolateral mem
Cell signal = cyclic amp production
Aquaporin produced at apical mem

6

What is diabetes insipidus

Hereditary disorder which causes individual to produce large volumes of dilute urine, constantly thirsty,
Treat = ADH supplement

7

What are the two types of diabetes insipidus and what do they mean

Central - cannot make ADH
Nephrogenic- can make ADH as norm,a but cannot exert its affect on target cells

8

What is the secondary production site of ADH

Left atrial stretch receptors

9

What do the stretch receptors in the GI tract do

Forward feeding activation or inhibition of ADH
Too much fluid activate ADH
Too little inhibit ADH

10

What is aldosterone

Steroid hormone

11

Wher is aldosterone produced

Adrenal cortex of adrenal gland

12

How does the body cope with the changes in body fluid volume

Filtration --> changes in blood pressure and size of filtration slits
Secretion and re absorption --> changes in solution concentration
Excretion --> bladder function under renal control

13

What does aldosterone do

Stimulates sodium reabs and pottasium sec

14

When is aldosterone sec

Response to rising pottasium in las a conc of blood
If decrease in sodium

15

What are the granular cells of the juxtmedullary sensitive to

Afferent arteriole pressure

16

If there is an increased symp activity as a result of reduced arterial blood pressure what would this mean

Granular renin sec cells are directly innervated by symp nervous system causes renin release

17

What can abnormal increases in RAA system increase

Hypertension

18

What produced atrial natriuretic peptide ANP

Heart produces and stored in atrial smooth muscle

19

When is ANP released

When the smooth muscle cells are stretched due to increased plasma volume

20

What does ANP do

Promote excretion of sodium osmotic effect and dieresis decreasing plasma volume
Effect CVS to lower blood pressure

21

What happens in water dieresis

Increased urine flow but not an increased solute excretion

22

What happens in osmotic dieresis

Increased urine flow is as result of a primarily increase in salt excretion