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Flashcards in Renal Phys--> look of Henle Deck (14):
1

What makes up the Loop and Henle?

Thin descending limb
Thin ascending limb
Thick ascending limb

2

Which limb is permeable to water and not solute? Which is vice versa?

Descending
Ascending, respectively

3

What is the Na:water absorption in the loop? What does this create/

25%:10%
- creates different osmolality in filtrate than plasma
- lumen goes from 300 to 100 mOsms after the loop

4

If you go from 300 to 100 mOsms are you diluting or concentrating?

Diluting

5

What is the NKCC2 transporter?

Transports
Na
K
2CL
- Found in thick ascending limb
- all sites must be occupied to work

6

What does 2Cl to Na ratio create in the lumen? What does this cause?

Creates slight positive charge in lumen
- pushes Ca, Mg and Na out of lumen filtrate via paracellular transport

7

What is being recycled in the loop? What percent? By what transporter?

K+
90%
ROMK
- Critical to keep NKCC2 channel running. Because all sites must be occupied to work

8

What is a Bartton Channel?

Channel which Cl- leaves cell via basolateral side
- Via down conc. gradient

9

What is another way Cl can leave the cell?

K+ synporter on basolateral side

10

how much Na does the NKCC channel absorb? Ca? Mg?

25% of filtered load
- 20% Ca
- 50-60% Mg

11

What upregulates NKCC?

AgII
ADH

12

What is Bartter Syndrome?

Any disorder affecting transporters in the thick ascending limb
- either directly or indirectly affects NKCC2
- HypoNa+ leads to hypovolemia
- Hypokalemia
- normal to elevated urinary Ca excretion
- metabolic alkalosis
- Growth retardation

13

What is the conc. of Na after the loop?

about 50mM

14

What is something that can downregulate the NKCC channel?

Ca sensitive receptors
- to much calcium can downregulate NKCC