Flashcards in Renal Phys--> look of Henle Deck (14):
What makes up the Loop and Henle?
Thin descending limb
Thin ascending limb
Thick ascending limb
Which limb is permeable to water and not solute? Which is vice versa?
What is the Na:water absorption in the loop? What does this create/
- creates different osmolality in filtrate than plasma
- lumen goes from 300 to 100 mOsms after the loop
If you go from 300 to 100 mOsms are you diluting or concentrating?
What is the NKCC2 transporter?
- Found in thick ascending limb
- all sites must be occupied to work
What does 2Cl to Na ratio create in the lumen? What does this cause?
Creates slight positive charge in lumen
- pushes Ca, Mg and Na out of lumen filtrate via paracellular transport
What is being recycled in the loop? What percent? By what transporter?
- Critical to keep NKCC2 channel running. Because all sites must be occupied to work
What is a Bartton Channel?
Channel which Cl- leaves cell via basolateral side
- Via down conc. gradient
What is another way Cl can leave the cell?
K+ synporter on basolateral side
how much Na does the NKCC channel absorb? Ca? Mg?
25% of filtered load
- 20% Ca
- 50-60% Mg
What upregulates NKCC?
What is Bartter Syndrome?
Any disorder affecting transporters in the thick ascending limb
- either directly or indirectly affects NKCC2
- HypoNa+ leads to hypovolemia
- normal to elevated urinary Ca excretion
- metabolic alkalosis
- Growth retardation
What is the conc. of Na after the loop?