Renal Proximal Tubule And The Loop Of Henle Flashcards Preview

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Flashcards in Renal Proximal Tubule And The Loop Of Henle Deck (29):
1

What is reabsorbed in the proximal tubule

Sugars
Amino acids
Phosohate
Sulphate
Lactate

2

What is secreted in the proximal tubule

Hydrogen ions
Hippurates
Neurotransmitters
Bile pigments
Uric acid
Drugs
Toxins

3

What is trans cellular

Though the cell

4

What is para cellular

Betweent he epithelia cells

5

What is primary active transport

Energy is directly required to operate the carrier and move the substrate against its conc grad

6

What is secondary active trans

Carrier mol transported coupled to conc grad of an ion usually sodium

7

What is facilitated diffusion

Passive carrier mediated transport of a substance down its conc grad

8

Where are sodium pottasium pumps found

Basolateral mem

9

How does isoosmotic fluid reabs across leaky proximal tubule epithelia occur

Standing osmotic grad
Oncotic pressure grad

10

What is glucose abs in proximal tubule

100% of glucose in filtrate reabs in proximal tubule

11

What is the transport maximum of glucose

2mmol/min

12

67% of what is reabs in PT and what is reabs 100%

67% - salts water
100% - glucose and amino acids

13

What is the function of the loop of Henle

Generate a cortico-medullary solute conc grad
Form hypertonic urine

14

What is the fluid flow like in the loop of Henle

Opposing flow in two limbs countercurrent flow
The entire loop = countercurrent multiplier
Together the loop and vasa recta establish a hyper-osmotic medullary interstitial fluid

15

What happens along the ascending limb of the lop of Henle

Along entire length sodium a dn chloride reabs
In ticker parts this is done via active trans while done by passively in thinner parts

This part is relatively perm to water this inflicts upon salt reabs

16

What happens in the descending loop of Henle

Does not reabs sodium chloride highly preamble to water

17

Where is the triple co transporter and what does this do

On luminal surface of epi cell
Moves sodium, pottasium and chloride into cell

18

What does pottasium recycling mean

Means that sodium chloride is abs into interstitial fluid

19

What does loop dietetics do to triple co transporter

Blocks it

20

How does urea pass into loop

Passively diffuse

21

What does ureas
Do to the interstitium

Adds solute

22

Where is not preamble to urea

Distal tubule

23

What is the purpose of the countercurrent multiplication

To concentrate the medially interstitial fluid

24

Why is he medulla interstitial fluid concentrated

To enable kidneys to produce urnie to diff volume and concentration according to amounts of circulating ADH

25

What happens to the blood osmolarity as the loop of Henle dips into medulla and back up

Osmolarity rises as dips into medulla as water lost and salt gained

Osmolarity falls as loop up into cortex as water gained and the solute lost

26

What acts as a countercurrent exchanger

The vasa recta

27

What is the vasa react fully perm to

Nacl and water

28

What creates the medullary osmotic grad

Countercurrent multiplier
Urea cycle
This gradientpreserved by countercurrent exchanger

29

The fluid reabs in the proximal tubule is what with filtrate

iOS osmotic